Marked Improvement in Refractory TTP Directly after H. pylori Eradication Therapy
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder involving thrombotic microangiopathy and is characterized by increased platelet aggregation throughout the body. Acquired TTP can be triggered by a variety of conditions including infections. We hereby describe a case report of...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2016/1568586 |
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| author | Irina Gringauz Narin Nard Carmel-Neiderman Tobin Mangel Orith Portnoy Gad Segal Idan Goren |
| author_facet | Irina Gringauz Narin Nard Carmel-Neiderman Tobin Mangel Orith Portnoy Gad Segal Idan Goren |
| author_sort | Irina Gringauz |
| collection | DOAJ |
| description | Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder involving thrombotic microangiopathy and is characterized by increased platelet aggregation throughout the body. Acquired TTP can be triggered by a variety of conditions including infections. We hereby describe a case report of an 81-year-old female presenting to the internal medicine department with TTP and active chronic gastritis, positive for Helicobacter pylori (H. pylori) on biopsy. The TTP was highly resistant to medical therapy; however the patient underwent complete resolution of her TTP following H. pylori eradication. We conclude that acquired TTP may be triggered by H. pylori infection and that treating the underlying infection may play a role in improving TTP’s outcome in some patients, especially when disease is refractory to medical therapy. |
| format | Article |
| id | doaj-art-ba980ec1f8f94dd3be2c739836130fc7 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-ba980ec1f8f94dd3be2c739836130fc72025-02-03T06:05:59ZengWileyCase Reports in Hematology2090-65602090-65792016-01-01201610.1155/2016/15685861568586Marked Improvement in Refractory TTP Directly after H. pylori Eradication TherapyIrina Gringauz0Narin Nard Carmel-Neiderman1Tobin Mangel2Orith Portnoy3Gad Segal4Idan Goren5Internal Medicine Ward T, Sheba Medical Center, Tel Hashomer, Ramat Gan, IsraelHasharon Hospital, Campus Rabin, Petah Tikva, IsraelSt George’s University of London, London, UKDepartment of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer, Ramat Gan, IsraelInternal Medicine Ward T, Sheba Medical Center, Tel Hashomer, Ramat Gan, IsraelInternal Medicine Ward T, Sheba Medical Center, Tel Hashomer, Ramat Gan, IsraelThrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder involving thrombotic microangiopathy and is characterized by increased platelet aggregation throughout the body. Acquired TTP can be triggered by a variety of conditions including infections. We hereby describe a case report of an 81-year-old female presenting to the internal medicine department with TTP and active chronic gastritis, positive for Helicobacter pylori (H. pylori) on biopsy. The TTP was highly resistant to medical therapy; however the patient underwent complete resolution of her TTP following H. pylori eradication. We conclude that acquired TTP may be triggered by H. pylori infection and that treating the underlying infection may play a role in improving TTP’s outcome in some patients, especially when disease is refractory to medical therapy.http://dx.doi.org/10.1155/2016/1568586 |
| spellingShingle | Irina Gringauz Narin Nard Carmel-Neiderman Tobin Mangel Orith Portnoy Gad Segal Idan Goren Marked Improvement in Refractory TTP Directly after H. pylori Eradication Therapy Case Reports in Hematology |
| title | Marked Improvement in Refractory TTP Directly after H. pylori Eradication Therapy |
| title_full | Marked Improvement in Refractory TTP Directly after H. pylori Eradication Therapy |
| title_fullStr | Marked Improvement in Refractory TTP Directly after H. pylori Eradication Therapy |
| title_full_unstemmed | Marked Improvement in Refractory TTP Directly after H. pylori Eradication Therapy |
| title_short | Marked Improvement in Refractory TTP Directly after H. pylori Eradication Therapy |
| title_sort | marked improvement in refractory ttp directly after h pylori eradication therapy |
| url | http://dx.doi.org/10.1155/2016/1568586 |
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