Ziziphus jujube promotes fertility and pregnancy outcomes in Rat model of uterine adhesions
IntroductionThe therapeutic efficacy of oral administration of Ziziphus jujube in the context of uterine adhesion (UA) and its impact on pregnancy outcomes was investigated.MethodsIn a rat UA model, Z. jujube was evaluated for its ability to mitigate injury-induced uterine adhesion bands, uterine sh...
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2025-01-01
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| author | Fereshteh Asgharzadeh Fereshteh Asgharzadeh Mahsa Attarian Majid Khazaei Majid Khazaei Abdulridha Mohammed Al-Asady Abdulridha Mohammed Al-Asady Abdulridha Mohammed Al-Asady Saeide Mansoori Hamideh Naimi Moein Eskandari Azar Khorrami Seyedeh Elnaz Nazari Akram Aminian Marjaneh Farazastanian Elaheh Eshtad Amir Avan Amir Avan Mikhail Ryzhikov Malihe Hasanzadeh Seyed Mahdi Hassanian Seyed Mahdi Hassanian |
| author_facet | Fereshteh Asgharzadeh Fereshteh Asgharzadeh Mahsa Attarian Majid Khazaei Majid Khazaei Abdulridha Mohammed Al-Asady Abdulridha Mohammed Al-Asady Abdulridha Mohammed Al-Asady Saeide Mansoori Hamideh Naimi Moein Eskandari Azar Khorrami Seyedeh Elnaz Nazari Akram Aminian Marjaneh Farazastanian Elaheh Eshtad Amir Avan Amir Avan Mikhail Ryzhikov Malihe Hasanzadeh Seyed Mahdi Hassanian Seyed Mahdi Hassanian |
| author_sort | Fereshteh Asgharzadeh |
| collection | DOAJ |
| description | IntroductionThe therapeutic efficacy of oral administration of Ziziphus jujube in the context of uterine adhesion (UA) and its impact on pregnancy outcomes was investigated.MethodsIn a rat UA model, Z. jujube was evaluated for its ability to mitigate injury-induced uterine adhesion bands, uterine shortening, and enhance endometrial regeneration. The assessment included analysis of gland numbers, uterine endometrial thickness, and regulation of inflammatory cytokines. The antioxidant properties of Z. jujube were also studied through antioxidant enzyme activity in uterine tissue homogenates. Fibrotic changes were examined through histological Trichrome staining and analysis of pro-fibrotic factors.ResultsTreatment with Z. jujube resulted in a significant reduction in uterine tissue fibrosis, as evidenced by histological evaluation and reduced expression of fibrotic markers. The intervention demonstrated positive outcomes in embryonic development, pregnancy rates, and pregnancy outcomes. Z. jujube effectively inhibited the formation of extra-uterine adhesion bands to internal organs. No toxicity-related morphological changes were observed in vital organs of the Z. Jujube-treated group.DiscussionThe results collectively indicate that Z. jujube is a safe and potent natural product with anti-inflammatory and anti-fibrotic properties, highlighting its potential as a novel candidate for clinical studies targeting UA in patients. |
| format | Article |
| id | doaj-art-ba977a7032a6490e96c11759e4849493 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Frontiers in Pharmacology |
| spelling | doaj-art-ba977a7032a6490e96c11759e48494932025-01-27T06:40:14ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.14961361496136Ziziphus jujube promotes fertility and pregnancy outcomes in Rat model of uterine adhesionsFereshteh Asgharzadeh0Fereshteh Asgharzadeh1Mahsa Attarian2Majid Khazaei3Majid Khazaei4Abdulridha Mohammed Al-Asady5Abdulridha Mohammed Al-Asady6Abdulridha Mohammed Al-Asady7Saeide Mansoori8Hamideh Naimi9Moein Eskandari10Azar Khorrami11Seyedeh Elnaz Nazari12Akram Aminian13Marjaneh Farazastanian14Elaheh Eshtad15Amir Avan16Amir Avan17Mikhail Ryzhikov18Malihe Hasanzadeh19Seyed Mahdi Hassanian20Seyed Mahdi Hassanian21Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Medical Sciences, Faculty of Nursing, Warith Al-Anbiyaa University, Kerbala, IraqDepartment of Medical Sciences, Faculty of Dentistry, University of Kerbala, Kerbala, IraqDepartment of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranMedical School, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Physiology and Pharmacology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, IranDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran0Department of Human Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran1School of Medicine, Saint Louis University, Saint Louis, MO, United StatesDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranIntroductionThe therapeutic efficacy of oral administration of Ziziphus jujube in the context of uterine adhesion (UA) and its impact on pregnancy outcomes was investigated.MethodsIn a rat UA model, Z. jujube was evaluated for its ability to mitigate injury-induced uterine adhesion bands, uterine shortening, and enhance endometrial regeneration. The assessment included analysis of gland numbers, uterine endometrial thickness, and regulation of inflammatory cytokines. The antioxidant properties of Z. jujube were also studied through antioxidant enzyme activity in uterine tissue homogenates. Fibrotic changes were examined through histological Trichrome staining and analysis of pro-fibrotic factors.ResultsTreatment with Z. jujube resulted in a significant reduction in uterine tissue fibrosis, as evidenced by histological evaluation and reduced expression of fibrotic markers. The intervention demonstrated positive outcomes in embryonic development, pregnancy rates, and pregnancy outcomes. Z. jujube effectively inhibited the formation of extra-uterine adhesion bands to internal organs. No toxicity-related morphological changes were observed in vital organs of the Z. Jujube-treated group.DiscussionThe results collectively indicate that Z. jujube is a safe and potent natural product with anti-inflammatory and anti-fibrotic properties, highlighting its potential as a novel candidate for clinical studies targeting UA in patients.https://www.frontiersin.org/articles/10.3389/fphar.2024.1496136/fullZiziphus jujubeuterine adhesionpregnancy outcomesendometrial regenerationAsherman’s syndromeembryonic development |
| spellingShingle | Fereshteh Asgharzadeh Fereshteh Asgharzadeh Mahsa Attarian Majid Khazaei Majid Khazaei Abdulridha Mohammed Al-Asady Abdulridha Mohammed Al-Asady Abdulridha Mohammed Al-Asady Saeide Mansoori Hamideh Naimi Moein Eskandari Azar Khorrami Seyedeh Elnaz Nazari Akram Aminian Marjaneh Farazastanian Elaheh Eshtad Amir Avan Amir Avan Mikhail Ryzhikov Malihe Hasanzadeh Seyed Mahdi Hassanian Seyed Mahdi Hassanian Ziziphus jujube promotes fertility and pregnancy outcomes in Rat model of uterine adhesions Frontiers in Pharmacology Ziziphus jujube uterine adhesion pregnancy outcomes endometrial regeneration Asherman’s syndrome embryonic development |
| title | Ziziphus jujube promotes fertility and pregnancy outcomes in Rat model of uterine adhesions |
| title_full | Ziziphus jujube promotes fertility and pregnancy outcomes in Rat model of uterine adhesions |
| title_fullStr | Ziziphus jujube promotes fertility and pregnancy outcomes in Rat model of uterine adhesions |
| title_full_unstemmed | Ziziphus jujube promotes fertility and pregnancy outcomes in Rat model of uterine adhesions |
| title_short | Ziziphus jujube promotes fertility and pregnancy outcomes in Rat model of uterine adhesions |
| title_sort | ziziphus jujube promotes fertility and pregnancy outcomes in rat model of uterine adhesions |
| topic | Ziziphus jujube uterine adhesion pregnancy outcomes endometrial regeneration Asherman’s syndrome embryonic development |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1496136/full |
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