Ziziphus jujube promotes fertility and pregnancy outcomes in Rat model of uterine adhesions

Ziziphus jujube promotes fertility and pregnancy outcomes in Rat model of uterine adhesions

IntroductionThe therapeutic efficacy of oral administration of Ziziphus jujube in the context of uterine adhesion (UA) and its impact on pregnancy outcomes was investigated.MethodsIn a rat UA model, Z. jujube was evaluated for its ability to mitigate injury-induced uterine adhesion bands, uterine sh...

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Main Authors: Fereshteh Asgharzadeh, Mahsa Attarian, Majid Khazaei, Abdulridha Mohammed Al-Asady, Saeide Mansoori, Hamideh Naimi, Moein Eskandari, Azar Khorrami, Seyedeh Elnaz Nazari, Akram Aminian, Marjaneh Farazastanian, Elaheh Eshtad, Amir Avan, Mikhail Ryzhikov, Malihe Hasanzadeh, Seyed Mahdi Hassanian
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
Ziziphus jujube
uterine adhesion
pregnancy outcomes
endometrial regeneration
Asherman’s syndrome
embryonic development
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1496136/full
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Summary:IntroductionThe therapeutic efficacy of oral administration of Ziziphus jujube in the context of uterine adhesion (UA) and its impact on pregnancy outcomes was investigated.MethodsIn a rat UA model, Z. jujube was evaluated for its ability to mitigate injury-induced uterine adhesion bands, uterine shortening, and enhance endometrial regeneration. The assessment included analysis of gland numbers, uterine endometrial thickness, and regulation of inflammatory cytokines. The antioxidant properties of Z. jujube were also studied through antioxidant enzyme activity in uterine tissue homogenates. Fibrotic changes were examined through histological Trichrome staining and analysis of pro-fibrotic factors.ResultsTreatment with Z. jujube resulted in a significant reduction in uterine tissue fibrosis, as evidenced by histological evaluation and reduced expression of fibrotic markers. The intervention demonstrated positive outcomes in embryonic development, pregnancy rates, and pregnancy outcomes. Z. jujube effectively inhibited the formation of extra-uterine adhesion bands to internal organs. No toxicity-related morphological changes were observed in vital organs of the Z. Jujube-treated group.DiscussionThe results collectively indicate that Z. jujube is a safe and potent natural product with anti-inflammatory and anti-fibrotic properties, highlighting its potential as a novel candidate for clinical studies targeting UA in patients.
ISSN:1663-9812

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