Deep visual proteomics reveals DNA replication stress as a hallmark of signet ring cell carcinoma
Abstract Signet Ring Cell Carcinoma (SRCC) is a rare and highly malignant form of adenocarcinoma with increasing incidence and poor prognosis due to late diagnosis and limited treatment options. We employed Deep Visual Proteomics (DVP), which combines AI-directed cell segmentation and classification...
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Main Authors: | Sonja Kabatnik, Xiang Zheng, Georgios Pappas, Sophia Steigerwald, Matthew P. Padula, Matthias Mann |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2025-02-01
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Series: | npj Precision Oncology |
Online Access: | https://doi.org/10.1038/s41698-025-00819-7 |
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