Iron Chelation Therapy in Myelodysplastic Syndromes
Myelodysplastic syndromes (MDS) are a heterogeneous disorder of the hematopoietic stem cells, frequently characterized by anemia and transfusion dependency. In low-risk patients, transfusion dependency can be long lasting, leading to iron overload. Iron chelation therapy may be a therapeutic option...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2010/756289 |
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| author | Emanuela Messa Daniela Cilloni Giuseppe Saglio |
| author_facet | Emanuela Messa Daniela Cilloni Giuseppe Saglio |
| author_sort | Emanuela Messa |
| collection | DOAJ |
| description | Myelodysplastic syndromes (MDS) are a heterogeneous disorder of the hematopoietic stem cells, frequently characterized by anemia and transfusion dependency. In low-risk patients, transfusion dependency can be long lasting, leading to iron overload. Iron chelation therapy may be a therapeutic option for these patients, especially since the approval of oral iron chelators, which are easier to use and better accepted by the patients. The usefulness of iron chelation in MDS patients is still under debate, mainly because of the lack of solid prospective clinical trials that should take place in the future. This review aims to summarize what is currently known about the incidence and clinical consequences of iron overload in MDS patients and the state-of the-art of iron chelation therapy in this setting. We also give an overview of clinical guidelines for chelation in MDS published to date and some perspectives for the future. |
| format | Article |
| id | doaj-art-ba921c3658aa40f9adc87c898c9482ca |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-ba921c3658aa40f9adc87c898c9482ca2025-02-03T01:31:21ZengWileyAdvances in Hematology1687-91041687-91122010-01-01201010.1155/2010/756289756289Iron Chelation Therapy in Myelodysplastic SyndromesEmanuela Messa0Daniela Cilloni1Giuseppe Saglio2Division of Hematology and Internal Medicine, Department of Clinical and Biological Sciences of the University of Turin, Regione Gonzole 10, 10043 Orbassano (To), ItalyDivision of Hematology and Internal Medicine, Department of Clinical and Biological Sciences of the University of Turin, Regione Gonzole 10, 10043 Orbassano (To), ItalyDivision of Hematology and Internal Medicine, Department of Clinical and Biological Sciences of the University of Turin, Regione Gonzole 10, 10043 Orbassano (To), ItalyMyelodysplastic syndromes (MDS) are a heterogeneous disorder of the hematopoietic stem cells, frequently characterized by anemia and transfusion dependency. In low-risk patients, transfusion dependency can be long lasting, leading to iron overload. Iron chelation therapy may be a therapeutic option for these patients, especially since the approval of oral iron chelators, which are easier to use and better accepted by the patients. The usefulness of iron chelation in MDS patients is still under debate, mainly because of the lack of solid prospective clinical trials that should take place in the future. This review aims to summarize what is currently known about the incidence and clinical consequences of iron overload in MDS patients and the state-of the-art of iron chelation therapy in this setting. We also give an overview of clinical guidelines for chelation in MDS published to date and some perspectives for the future.http://dx.doi.org/10.1155/2010/756289 |
| spellingShingle | Emanuela Messa Daniela Cilloni Giuseppe Saglio Iron Chelation Therapy in Myelodysplastic Syndromes Advances in Hematology |
| title | Iron Chelation Therapy in Myelodysplastic Syndromes |
| title_full | Iron Chelation Therapy in Myelodysplastic Syndromes |
| title_fullStr | Iron Chelation Therapy in Myelodysplastic Syndromes |
| title_full_unstemmed | Iron Chelation Therapy in Myelodysplastic Syndromes |
| title_short | Iron Chelation Therapy in Myelodysplastic Syndromes |
| title_sort | iron chelation therapy in myelodysplastic syndromes |
| url | http://dx.doi.org/10.1155/2010/756289 |
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