Monoclonal Gammopathy of Undetermined Significance (MGUS) in a Man with Fragile X-associated Tremor/Ataxia Syndrome
We report the clinical presentation and laboratory findings of a 69-year-old man with fragile X-associated tremor ataxia syndrome (FXTAS), a progressive neurodegenerative disorder, who was noted to have monoclonal gammopathy of undetermined significance (MGUS), a plasma cell proliferative disorder a...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Genetics |
| Online Access: | http://dx.doi.org/10.1155/2011/143132 |
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| author | Tanjung A. Sumekar Aneel A. Ashrani Tri I. Winarni Randi J. Hagerman |
| author_facet | Tanjung A. Sumekar Aneel A. Ashrani Tri I. Winarni Randi J. Hagerman |
| author_sort | Tanjung A. Sumekar |
| collection | DOAJ |
| description | We report the clinical presentation and laboratory findings of a 69-year-old man with fragile X-associated tremor ataxia syndrome (FXTAS), a progressive neurodegenerative disorder, who was noted to have monoclonal gammopathy of undetermined significance (MGUS), a plasma cell proliferative disorder and a precursor disease of multiple myeloma. Both MGUS and FXTAS are associated with microRNA (miRNA) dysregulation. We speculate that individuals with FXTAS may be predisposed to MGUS and further studies are warranted regarding this association. |
| format | Article |
| id | doaj-art-ba82e4044c2e4015a2a674359f7d3521 |
| institution | Kabale University |
| issn | 2090-6544 2090-6552 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Genetics |
| spelling | doaj-art-ba82e4044c2e4015a2a674359f7d35212025-02-03T06:47:53ZengWileyCase Reports in Genetics2090-65442090-65522011-01-01201110.1155/2011/143132143132Monoclonal Gammopathy of Undetermined Significance (MGUS) in a Man with Fragile X-associated Tremor/Ataxia SyndromeTanjung A. Sumekar0Aneel A. Ashrani1Tri I. Winarni2Randi J. Hagerman3Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, Davis Medical Center, University of California, 2825 50th Street, Sacramento, CA 95817, USADivision of Hematology, Department of Internal Medicine, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USAMedical Investigation of Neurodevelopmental Disorders (MIND) Institute, Davis Medical Center, University of California, 2825 50th Street, Sacramento, CA 95817, USAMedical Investigation of Neurodevelopmental Disorders (MIND) Institute, Davis Medical Center, University of California, 2825 50th Street, Sacramento, CA 95817, USAWe report the clinical presentation and laboratory findings of a 69-year-old man with fragile X-associated tremor ataxia syndrome (FXTAS), a progressive neurodegenerative disorder, who was noted to have monoclonal gammopathy of undetermined significance (MGUS), a plasma cell proliferative disorder and a precursor disease of multiple myeloma. Both MGUS and FXTAS are associated with microRNA (miRNA) dysregulation. We speculate that individuals with FXTAS may be predisposed to MGUS and further studies are warranted regarding this association.http://dx.doi.org/10.1155/2011/143132 |
| spellingShingle | Tanjung A. Sumekar Aneel A. Ashrani Tri I. Winarni Randi J. Hagerman Monoclonal Gammopathy of Undetermined Significance (MGUS) in a Man with Fragile X-associated Tremor/Ataxia Syndrome Case Reports in Genetics |
| title | Monoclonal Gammopathy of Undetermined Significance (MGUS) in a Man with Fragile X-associated Tremor/Ataxia Syndrome |
| title_full | Monoclonal Gammopathy of Undetermined Significance (MGUS) in a Man with Fragile X-associated Tremor/Ataxia Syndrome |
| title_fullStr | Monoclonal Gammopathy of Undetermined Significance (MGUS) in a Man with Fragile X-associated Tremor/Ataxia Syndrome |
| title_full_unstemmed | Monoclonal Gammopathy of Undetermined Significance (MGUS) in a Man with Fragile X-associated Tremor/Ataxia Syndrome |
| title_short | Monoclonal Gammopathy of Undetermined Significance (MGUS) in a Man with Fragile X-associated Tremor/Ataxia Syndrome |
| title_sort | monoclonal gammopathy of undetermined significance mgus in a man with fragile x associated tremor ataxia syndrome |
| url | http://dx.doi.org/10.1155/2011/143132 |
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