HMGB-1 as a predictor of major bleeding requiring activation of a massive transfusion protocol in severe trauma

HMGB-1 as a predictor of major bleeding requiring activation of a massive transfusion protocol in severe trauma

Abstract Massive bleeding causes approximately 50% of deaths in patients with major trauma. Most patients die within 6 h of injury, which is preventable in at least 10% of cases. For these patients, early activation of the massive transfusion protocol (MTP) is a critical survival factor. With severe...

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Main Authors: Michal Frelich, Marek Bebej, Jan Pavlíček, Filip Burša, Vojtěch Vodička, Zdeněk Švagera, Adéla Kondé, Ondřej Jor, Markéta Bílená, Tereza Romanová, Peter Sklienka
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Major trauma
Bleeding
Massive transfusion protocol
HMGB-1
Online Access:https://doi.org/10.1038/s41598-025-89139-1
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