Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study
Objective. This study aimed at investigating the therapeutic effect and mechanism of pioglitazone metformin complex preparation (PM) in polycystic ovary syndrome (PCOS) comorbid psychological distress. Methods. Seventy-five patients with PCOS comorbid psychological distress were randomly allocated i...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/3050487 |
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| author | Qing-jun Guo Jing Shan Yi-feng Xu Yan-yan Hu Cui-lan Huo Jing-yun Song Chao-qun Wang Hui Zhou Chao-qin Yu Qin Huang |
| author_facet | Qing-jun Guo Jing Shan Yi-feng Xu Yan-yan Hu Cui-lan Huo Jing-yun Song Chao-qun Wang Hui Zhou Chao-qin Yu Qin Huang |
| author_sort | Qing-jun Guo |
| collection | DOAJ |
| description | Objective. This study aimed at investigating the therapeutic effect and mechanism of pioglitazone metformin complex preparation (PM) in polycystic ovary syndrome (PCOS) comorbid psychological distress. Methods. Seventy-five patients with PCOS comorbid psychological distress were randomly allocated into the PM, metformin, and placebo groups. The primary efficacy measure was the change from baseline to week 12 on the Symptom Checklist 90-R (SCL-90-R) scores. NLRP3 inflammasome, IL-1β, IL-6, TNF-α, and biochemical parameters were determined at baseline and at week 12. The participants were required to meet the criteria for PCOS (Rotterdam, NIH) and psychological distress (any factor scores of SCL−90−R>2). Results. The participants had significantly high scores on the SCL-90-R scales of anxiety and depression. PM significantly decreased anxiety and depression symptom severity (from 2.31±0.75 to 1.65±0.38, p<0.001, and from 2.08±0.74 to 1.61±0.46, p=0.010, at week 12, respectively). PM significantly decreased the expression of NRPL3 and caspase-1. Patients in the PM group experienced a significant reduction in IL-1β (from 98.42±14.38 to 71.76±13.66, p=0.02), IL-6 (from 87.51±8.74 to 71.98±15.87, p=0.02), and TNF-α (from 395.33±88.55 to 281.98±85.69, p=0.04). PM was superior to metformin in reducing total testosterone (2.24±0.74 versus 3.06±0.83, p=0.024, at week 12).Conclusions. This study is the first to reveal that PM alleviates psychological distress via inhibiting NLRP3 inflammasome and improves several markers, including total testosterone. |
| format | Article |
| id | doaj-art-ba80a2d3cfe040cd9a7c0a3ab3a3350e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ba80a2d3cfe040cd9a7c0a3ab3a3350e2025-02-03T05:44:13ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/30504873050487Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical StudyQing-jun Guo0Jing Shan1Yi-feng Xu2Yan-yan Hu3Cui-lan Huo4Jing-yun Song5Chao-qun Wang6Hui Zhou7Chao-qin Yu8Qin Huang9Department of Endocrinology, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Endocrinology, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Endocrinology, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Endocrinology, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Endocrinology, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Endocrinology, Changhai Hospital, Naval Medical University, Shanghai, ChinaChangning Retirement Cadre Rest Care Clinic, Garrison District Shanghai, ChinaDepartment of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Endocrinology, Changhai Hospital, Naval Medical University, Shanghai, ChinaObjective. This study aimed at investigating the therapeutic effect and mechanism of pioglitazone metformin complex preparation (PM) in polycystic ovary syndrome (PCOS) comorbid psychological distress. Methods. Seventy-five patients with PCOS comorbid psychological distress were randomly allocated into the PM, metformin, and placebo groups. The primary efficacy measure was the change from baseline to week 12 on the Symptom Checklist 90-R (SCL-90-R) scores. NLRP3 inflammasome, IL-1β, IL-6, TNF-α, and biochemical parameters were determined at baseline and at week 12. The participants were required to meet the criteria for PCOS (Rotterdam, NIH) and psychological distress (any factor scores of SCL−90−R>2). Results. The participants had significantly high scores on the SCL-90-R scales of anxiety and depression. PM significantly decreased anxiety and depression symptom severity (from 2.31±0.75 to 1.65±0.38, p<0.001, and from 2.08±0.74 to 1.61±0.46, p=0.010, at week 12, respectively). PM significantly decreased the expression of NRPL3 and caspase-1. Patients in the PM group experienced a significant reduction in IL-1β (from 98.42±14.38 to 71.76±13.66, p=0.02), IL-6 (from 87.51±8.74 to 71.98±15.87, p=0.02), and TNF-α (from 395.33±88.55 to 281.98±85.69, p=0.04). PM was superior to metformin in reducing total testosterone (2.24±0.74 versus 3.06±0.83, p=0.024, at week 12).Conclusions. This study is the first to reveal that PM alleviates psychological distress via inhibiting NLRP3 inflammasome and improves several markers, including total testosterone.http://dx.doi.org/10.1155/2020/3050487 |
| spellingShingle | Qing-jun Guo Jing Shan Yi-feng Xu Yan-yan Hu Cui-lan Huo Jing-yun Song Chao-qun Wang Hui Zhou Chao-qin Yu Qin Huang Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study Mediators of Inflammation |
| title | Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study |
| title_full | Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study |
| title_fullStr | Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study |
| title_full_unstemmed | Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study |
| title_short | Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study |
| title_sort | pioglitazone metformin complex improves polycystic ovary syndrome comorbid psychological distress via inhibiting nlrp3 inflammasome activation a prospective clinical study |
| url | http://dx.doi.org/10.1155/2020/3050487 |
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