Assessment of Serum Vascular Endothelial Growth Factor Levels in Pregnancy-Induced Hypertension Patients
Objective. The objective of the study was to assess the serum vascular endothelial growth factor (VEGF) levels in peripheral blood of patients with pregnancy-induced hypertension (PIH) and find association between serum VEGF levels and PIH. Methods. Thirty-five PIH subjects, 35 normal pregnant femal...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2017/3179670 |
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| author | Vibha Tandon Swati Hiwale Dnyanesh Amle Tripti Nagaria Pradeep Kumar Patra |
| author_facet | Vibha Tandon Swati Hiwale Dnyanesh Amle Tripti Nagaria Pradeep Kumar Patra |
| author_sort | Vibha Tandon |
| collection | DOAJ |
| description | Objective. The objective of the study was to assess the serum vascular endothelial growth factor (VEGF) levels in peripheral blood of patients with pregnancy-induced hypertension (PIH) and find association between serum VEGF levels and PIH. Methods. Thirty-five PIH subjects, 35 normal pregnant females, and 20 normal healthy females were included in the study. Detailed history, clinical examination, and relevant biochemical parameters were assessed; serum VEGF levels were estimated using Double-antibody enzyme-linked immunosorbent assay. Results. The study groups were found to be age matched (p=0.38). VEGF level in the pregnancy-induced hypertensive group (median = 109.19 (3.38±619)) was significantly higher than the normal pregnant (median = 20.82 (1.7–619)) and control (median = 4.92 (1.13–13.07)) group and the difference between these three groups was significant (p<0.0001). The 3 groups are found to be significantly different in terms of RBS (p=0.01), urea (p<0.0001), creatinine (p=0.0005), AST (p=0.0032), ALT (p=0.0007), total protein (p=0.0004), albumin (p<0.0001), calcium (p=0.001), and sodium (p=0.02), while no statistically significant difference was found between total bilirubin (p=0.167), direct bilirubin (p=0.07), uric acid (p=0.16), and potassium (p=0.14). Conclusion. Significantly higher levels of serum VEGF were noted in PIH subjects compared to normal pregnant and control subjects. |
| format | Article |
| id | doaj-art-ba784e80607e49899bac25de244cc5af |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-ba784e80607e49899bac25de244cc5af2025-02-03T05:57:58ZengWileyJournal of Pregnancy2090-27272090-27352017-01-01201710.1155/2017/31796703179670Assessment of Serum Vascular Endothelial Growth Factor Levels in Pregnancy-Induced Hypertension PatientsVibha Tandon0Swati Hiwale1Dnyanesh Amle2Tripti Nagaria3Pradeep Kumar Patra4Department of Biochemistry, Pt. J.N.M. Medical College and Dr. B.R.A.M. Hospital, Raipur, Chhattisgarh, IndiaDepartment of Biochemistry, Pt. J.N.M. Medical College and Dr. B.R.A.M. Hospital, Raipur, Chhattisgarh, IndiaDepartment of Biochemistry, Pt. J.N.M. Medical College and Dr. B.R.A.M. Hospital, Raipur, Chhattisgarh, IndiaDepartment of Obstetrics and Gynaecology, Pt. J.N.M. Medical College and Dr. B.R.A.M. Hospital, Raipur, Chhattisgarh, IndiaDepartment of Biochemistry, Pt. J.N.M. Medical College and Dr. B.R.A.M. Hospital, Raipur, Chhattisgarh, IndiaObjective. The objective of the study was to assess the serum vascular endothelial growth factor (VEGF) levels in peripheral blood of patients with pregnancy-induced hypertension (PIH) and find association between serum VEGF levels and PIH. Methods. Thirty-five PIH subjects, 35 normal pregnant females, and 20 normal healthy females were included in the study. Detailed history, clinical examination, and relevant biochemical parameters were assessed; serum VEGF levels were estimated using Double-antibody enzyme-linked immunosorbent assay. Results. The study groups were found to be age matched (p=0.38). VEGF level in the pregnancy-induced hypertensive group (median = 109.19 (3.38±619)) was significantly higher than the normal pregnant (median = 20.82 (1.7–619)) and control (median = 4.92 (1.13–13.07)) group and the difference between these three groups was significant (p<0.0001). The 3 groups are found to be significantly different in terms of RBS (p=0.01), urea (p<0.0001), creatinine (p=0.0005), AST (p=0.0032), ALT (p=0.0007), total protein (p=0.0004), albumin (p<0.0001), calcium (p=0.001), and sodium (p=0.02), while no statistically significant difference was found between total bilirubin (p=0.167), direct bilirubin (p=0.07), uric acid (p=0.16), and potassium (p=0.14). Conclusion. Significantly higher levels of serum VEGF were noted in PIH subjects compared to normal pregnant and control subjects.http://dx.doi.org/10.1155/2017/3179670 |
| spellingShingle | Vibha Tandon Swati Hiwale Dnyanesh Amle Tripti Nagaria Pradeep Kumar Patra Assessment of Serum Vascular Endothelial Growth Factor Levels in Pregnancy-Induced Hypertension Patients Journal of Pregnancy |
| title | Assessment of Serum Vascular Endothelial Growth Factor Levels in Pregnancy-Induced Hypertension Patients |
| title_full | Assessment of Serum Vascular Endothelial Growth Factor Levels in Pregnancy-Induced Hypertension Patients |
| title_fullStr | Assessment of Serum Vascular Endothelial Growth Factor Levels in Pregnancy-Induced Hypertension Patients |
| title_full_unstemmed | Assessment of Serum Vascular Endothelial Growth Factor Levels in Pregnancy-Induced Hypertension Patients |
| title_short | Assessment of Serum Vascular Endothelial Growth Factor Levels in Pregnancy-Induced Hypertension Patients |
| title_sort | assessment of serum vascular endothelial growth factor levels in pregnancy induced hypertension patients |
| url | http://dx.doi.org/10.1155/2017/3179670 |
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