Does manipulation of phyto-based nanoparticles is a promising solution against multi-drug resistant (MDR) pathogens? A critical opinion towards tackling MDR pathogens
In recent decades, microbial resistance to antimicrobial drugs has emerged as a global health crisis. Therefore, it is crucial to develop alternative therapeutic strategies to address the growing threat of multi-drug resistant (MDR) pathogens. Researchers and clinicians are increasingly focusing...
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2024-09-01
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| Series: | Novel Research in Microbiology Journal |
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| Online Access: | https://nrmj.journals.ekb.eg/article_380744_c5820a98717dd82a7670a8fd2a9519eb.pdf |
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| author | Subhasmita Mallik Samikshya Nayak Arpita Panda Smrutirekha Behera Kamalakanta Swain Archita Patra Rukmini Mishra Jatindra Nath Mohanty |
| author_facet | Subhasmita Mallik Samikshya Nayak Arpita Panda Smrutirekha Behera Kamalakanta Swain Archita Patra Rukmini Mishra Jatindra Nath Mohanty |
| author_sort | Subhasmita Mallik |
| collection | DOAJ |
| description | In recent decades, microbial resistance to antimicrobial drugs has emerged as a global
health crisis. Therefore, it is crucial to develop alternative therapeutic strategies to address the
growing threat of multi-drug resistant (MDR) pathogens. Researchers and clinicians are
increasingly focusing on plant-based products due to their antibiotic properties and lack of
associated antibiotic resistance. Plant-based nanoparticles present several benefits, including
their natural origin, biocompatibility, and potential for targeted delivery. Our aims in this
review were exploration of the complexities and limitations of plant-based phytochemical
extraction processes and addressing the challenges of synthesizing nanoparticles for
combating multidrug-resistant (MDR) pathogens. It also examined the effectiveness of phytobased nanoparticles in drug delivery systems to treat MDR infections; both alone and in
combination with antibiotics, and provided a critical assessment of their potentials as a
research avenue. For this, we have taken the diverse methodologies that were previously used
to select the best possible process to tackle MDR pathogens using plant extracts. Although
using plant-derived products and nanoparticles is a novel approach to address the
antimicrobial drug resistance; however, detailed researches are necessary to explore their
antibacterial attributes. Specifically, transcriptome profiling should be employed to identify
therapeutic molecules from plant-based products that can effectively combat MDR bacteria
before synthesis of nano-drugs. The outcomes of this study will enable the researchers to
obtain the best approaches to tackle MDR pathogens through using the nano-based
phytochemicals. |
| format | Article |
| id | doaj-art-ba714a301b1c4b1aaf16933b84818cdc |
| institution | DOAJ |
| issn | 2537-0286 2537-0294 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | ResearchersLinks, Ltd |
| record_format | Article |
| series | Novel Research in Microbiology Journal |
| spelling | doaj-art-ba714a301b1c4b1aaf16933b84818cdc2025-08-20T03:22:52ZengResearchersLinks, LtdNovel Research in Microbiology Journal2537-02862537-02942024-09-01852604263110.21608/NRMJ.2024.306911.1663Does manipulation of phyto-based nanoparticles is a promising solution against multi-drug resistant (MDR) pathogens? A critical opinion towards tackling MDR pathogensSubhasmita Mallik0Samikshya Nayak1Arpita Panda2Smrutirekha Behera3Kamalakanta Swain4Archita Patra5Rukmini Mishra6Jatindra Nath Mohanty7Department of Botany, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, IndiaDepartment of Botany, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, IndiaDepartment of Zoology, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, IndiaDepartment of Botany, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, IndiaDepartment of Zoology, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, IndiaDepartment of Botany, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, IndiaDepartment of Botany, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, IndiaDepartment of Botany, School of Applied Sciences, Centurion University of Technology and Management, Jatni, Bhubaneswar- 752050, IndiaIn recent decades, microbial resistance to antimicrobial drugs has emerged as a global health crisis. Therefore, it is crucial to develop alternative therapeutic strategies to address the growing threat of multi-drug resistant (MDR) pathogens. Researchers and clinicians are increasingly focusing on plant-based products due to their antibiotic properties and lack of associated antibiotic resistance. Plant-based nanoparticles present several benefits, including their natural origin, biocompatibility, and potential for targeted delivery. Our aims in this review were exploration of the complexities and limitations of plant-based phytochemical extraction processes and addressing the challenges of synthesizing nanoparticles for combating multidrug-resistant (MDR) pathogens. It also examined the effectiveness of phytobased nanoparticles in drug delivery systems to treat MDR infections; both alone and in combination with antibiotics, and provided a critical assessment of their potentials as a research avenue. For this, we have taken the diverse methodologies that were previously used to select the best possible process to tackle MDR pathogens using plant extracts. Although using plant-derived products and nanoparticles is a novel approach to address the antimicrobial drug resistance; however, detailed researches are necessary to explore their antibacterial attributes. Specifically, transcriptome profiling should be employed to identify therapeutic molecules from plant-based products that can effectively combat MDR bacteria before synthesis of nano-drugs. The outcomes of this study will enable the researchers to obtain the best approaches to tackle MDR pathogens through using the nano-based phytochemicals. https://nrmj.journals.ekb.eg/article_380744_c5820a98717dd82a7670a8fd2a9519eb.pdfphyto-based nanoparticlesmdr pathogenstackling strategiesnano drugs |
| spellingShingle | Subhasmita Mallik Samikshya Nayak Arpita Panda Smrutirekha Behera Kamalakanta Swain Archita Patra Rukmini Mishra Jatindra Nath Mohanty Does manipulation of phyto-based nanoparticles is a promising solution against multi-drug resistant (MDR) pathogens? A critical opinion towards tackling MDR pathogens Novel Research in Microbiology Journal phyto-based nanoparticles mdr pathogens tackling strategies nano drugs |
| title | Does manipulation of phyto-based nanoparticles is a promising solution against multi-drug resistant (MDR) pathogens? A critical opinion towards tackling MDR pathogens |
| title_full | Does manipulation of phyto-based nanoparticles is a promising solution against multi-drug resistant (MDR) pathogens? A critical opinion towards tackling MDR pathogens |
| title_fullStr | Does manipulation of phyto-based nanoparticles is a promising solution against multi-drug resistant (MDR) pathogens? A critical opinion towards tackling MDR pathogens |
| title_full_unstemmed | Does manipulation of phyto-based nanoparticles is a promising solution against multi-drug resistant (MDR) pathogens? A critical opinion towards tackling MDR pathogens |
| title_short | Does manipulation of phyto-based nanoparticles is a promising solution against multi-drug resistant (MDR) pathogens? A critical opinion towards tackling MDR pathogens |
| title_sort | does manipulation of phyto based nanoparticles is a promising solution against multi drug resistant mdr pathogens a critical opinion towards tackling mdr pathogens |
| topic | phyto-based nanoparticles mdr pathogens tackling strategies nano drugs |
| url | https://nrmj.journals.ekb.eg/article_380744_c5820a98717dd82a7670a8fd2a9519eb.pdf |
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