Does manipulation of phyto-based nanoparticles is a promising solution against multi-drug resistant (MDR) pathogens? A critical opinion towards tackling MDR pathogens
In recent decades, microbial resistance to antimicrobial drugs has emerged as a global health crisis. Therefore, it is crucial to develop alternative therapeutic strategies to address the growing threat of multi-drug resistant (MDR) pathogens. Researchers and clinicians are increasingly focusing...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
ResearchersLinks, Ltd
2024-09-01
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| Series: | Novel Research in Microbiology Journal |
| Subjects: | |
| Online Access: | https://nrmj.journals.ekb.eg/article_380744_c5820a98717dd82a7670a8fd2a9519eb.pdf |
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| Summary: | In recent decades, microbial resistance to antimicrobial drugs has emerged as a global
health crisis. Therefore, it is crucial to develop alternative therapeutic strategies to address the
growing threat of multi-drug resistant (MDR) pathogens. Researchers and clinicians are
increasingly focusing on plant-based products due to their antibiotic properties and lack of
associated antibiotic resistance. Plant-based nanoparticles present several benefits, including
their natural origin, biocompatibility, and potential for targeted delivery. Our aims in this
review were exploration of the complexities and limitations of plant-based phytochemical
extraction processes and addressing the challenges of synthesizing nanoparticles for
combating multidrug-resistant (MDR) pathogens. It also examined the effectiveness of phytobased nanoparticles in drug delivery systems to treat MDR infections; both alone and in
combination with antibiotics, and provided a critical assessment of their potentials as a
research avenue. For this, we have taken the diverse methodologies that were previously used
to select the best possible process to tackle MDR pathogens using plant extracts. Although
using plant-derived products and nanoparticles is a novel approach to address the
antimicrobial drug resistance; however, detailed researches are necessary to explore their
antibacterial attributes. Specifically, transcriptome profiling should be employed to identify
therapeutic molecules from plant-based products that can effectively combat MDR bacteria
before synthesis of nano-drugs. The outcomes of this study will enable the researchers to
obtain the best approaches to tackle MDR pathogens through using the nano-based
phytochemicals. |
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| ISSN: | 2537-0286 2537-0294 |