Biclonal IgD and IgM Plasma Cell Myeloma: A Report of Two Cases and a Literature Review
Biclonal plasma cell myelomas producing two different isotypes of immunoglobulins are extremely rare entities; to date, the combination of IgD and IgM secretion by a biclonal plasma cell myeloma has not been reported. Bone marrow biopsy immunohistochemical studies in two cases revealed neoplastic pl...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/293150 |
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| author | Zhongchuan W. Chen Ioanna Kotsikogianni Jay S. Raval Christine G. Roth Marian A. Rollins-Raval |
| author_facet | Zhongchuan W. Chen Ioanna Kotsikogianni Jay S. Raval Christine G. Roth Marian A. Rollins-Raval |
| author_sort | Zhongchuan W. Chen |
| collection | DOAJ |
| description | Biclonal plasma cell myelomas producing two different isotypes of immunoglobulins are extremely rare entities; to date, the combination of IgD and IgM secretion by a biclonal plasma cell myeloma has not been reported. Bone marrow biopsy immunohistochemical studies in two cases revealed neoplastic plasma cells coexpressing IgD and IgM, but serum protein electrophoresis identified only the IgM monoclonal paraprotein in both cases. Biclonal plasma cell myelomas, while currently not well characterized in terms of their clinical behavior, should be distinguished from B-cell lymphoma with plasmacytic differentiation, given the different therapeutic implications. Both cases reported herein demonstrated chemotherapy-resistant clinical courses. |
| format | Article |
| id | doaj-art-ba66a453ff2d482e900ab5a99d9b980d |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-ba66a453ff2d482e900ab5a99d9b980d2025-02-03T06:01:50ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/293150293150Biclonal IgD and IgM Plasma Cell Myeloma: A Report of Two Cases and a Literature ReviewZhongchuan W. Chen0Ioanna Kotsikogianni1Jay S. Raval2Christine G. Roth3Marian A. Rollins-Raval4Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, M5S 1A1, CanadaPathology Laboratory, Patras General Hospital “O Agios Andreas,” 26500 Patras, GreeceDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USADepartment of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USADepartment of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USABiclonal plasma cell myelomas producing two different isotypes of immunoglobulins are extremely rare entities; to date, the combination of IgD and IgM secretion by a biclonal plasma cell myeloma has not been reported. Bone marrow biopsy immunohistochemical studies in two cases revealed neoplastic plasma cells coexpressing IgD and IgM, but serum protein electrophoresis identified only the IgM monoclonal paraprotein in both cases. Biclonal plasma cell myelomas, while currently not well characterized in terms of their clinical behavior, should be distinguished from B-cell lymphoma with plasmacytic differentiation, given the different therapeutic implications. Both cases reported herein demonstrated chemotherapy-resistant clinical courses.http://dx.doi.org/10.1155/2013/293150 |
| spellingShingle | Zhongchuan W. Chen Ioanna Kotsikogianni Jay S. Raval Christine G. Roth Marian A. Rollins-Raval Biclonal IgD and IgM Plasma Cell Myeloma: A Report of Two Cases and a Literature Review Case Reports in Hematology |
| title | Biclonal IgD and IgM Plasma Cell Myeloma: A Report of Two Cases and a Literature Review |
| title_full | Biclonal IgD and IgM Plasma Cell Myeloma: A Report of Two Cases and a Literature Review |
| title_fullStr | Biclonal IgD and IgM Plasma Cell Myeloma: A Report of Two Cases and a Literature Review |
| title_full_unstemmed | Biclonal IgD and IgM Plasma Cell Myeloma: A Report of Two Cases and a Literature Review |
| title_short | Biclonal IgD and IgM Plasma Cell Myeloma: A Report of Two Cases and a Literature Review |
| title_sort | biclonal igd and igm plasma cell myeloma a report of two cases and a literature review |
| url | http://dx.doi.org/10.1155/2013/293150 |
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