Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated
Background. Angiogenesis is a complex process involved in both growth and progression of several human and animal tumours. Tryptase is a serin protease stored in mast cells granules, which plays a role in tumour angiogenesis. Mast cells (MCs) can release tryptase following c-Kit receptor (c-KitR) a...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/703163 |
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| author | Michele Ammendola Rosario Sacco Giuseppe Sammarco Giuseppe Donato Valeria Zuccalà Roberto Romano Maria Luposella Rosa Patruno Carlo Vallicelli Giorgio Maria Verdecchia Davide Cavaliere Severino Montemurro Girolamo Ranieri |
| author_facet | Michele Ammendola Rosario Sacco Giuseppe Sammarco Giuseppe Donato Valeria Zuccalà Roberto Romano Maria Luposella Rosa Patruno Carlo Vallicelli Giorgio Maria Verdecchia Davide Cavaliere Severino Montemurro Girolamo Ranieri |
| author_sort | Michele Ammendola |
| collection | DOAJ |
| description | Background. Angiogenesis is a complex process involved in both growth and progression of several human and animal tumours. Tryptase is a serin protease stored in mast cells granules, which plays a role in tumour angiogenesis. Mast cells (MCs) can release tryptase following c-Kit receptor (c-KitR) activation.
Method. In a series of 25 gastric cancer patients with stage T3N2-3M0 (by AJCC for Gastric Cancer 7th Edition), immunohistochemistry and image analysis methods were employed to evaluate in the tumour tissue the correlation between the number of mast cells positive to tryptase (MCPT), c-KitR expressing cells (c-KitR-EC), and microvascular density (MVD). Results. Data demonstrated a positive correlation between MCPT, c-KitR-EC, and MVD to each other. In tumour tissue the mean number of MCPT was 15, the mean number of c-KitR-EC was 20, and the mean number of MVD was 20. The Pearson test correlating MCPT and MVD, c-KitR-EC and MVD was significantly (r=0.64, P=0.001; r=0.66, P=0.041, resp.). Conclusion. In this pilot study, we suggest that MCPT and c-KitR-EC play a role in gastric cancer angiogenesis, so we think that several c-KitR or tryptase inhibitors such as gabexate mesilate and nafamostat mesilate might be evaluated in clinical trials as a new antiangiogenetic approach. |
| format | Article |
| id | doaj-art-ba6676eaedbc4564ac5431dc431e2cb4 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-ba6676eaedbc4564ac5431dc431e2cb42025-02-03T01:08:49ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/703163703163Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically TreatedMichele Ammendola0Rosario Sacco1Giuseppe Sammarco2Giuseppe Donato3Valeria Zuccalà4Roberto Romano5Maria Luposella6Rosa Patruno7Carlo Vallicelli8Giorgio Maria Verdecchia9Davide Cavaliere10Severino Montemurro11Girolamo Ranieri12Department of Medical and Surgery Science, Clinical Surgery Unit, University of Catanzaro “Magna Graecia” Medical School, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Medical and Surgery Science, Clinical Surgery Unit, University of Catanzaro “Magna Graecia” Medical School, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Medical and Surgery Science, Clinical Surgery Unit, University of Catanzaro “Magna Graecia” Medical School, Viale Europa, Germaneto, 88100 Catanzaro, ItalyHealth Science Department, Pathology Unit, University of Catanzaro “Magna Graecia” Medical School, 88100 Catanzaro, ItalyHealth Science Department, Pathology Unit, University of Catanzaro “Magna Graecia” Medical School, 88100 Catanzaro, ItalyDepartment of Medical and Surgery Science, Clinical Surgery Unit, University of Catanzaro “Magna Graecia” Medical School, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Medical and Surgery Science, Cardiovascular Disease Unit, University of Catanzaro “Magna Graecia” Medical School, 88100 Catanzaro, ItalySurgery Unit, National Cancer Research Centre, Giovanni Paolo II, 70100 Bari, ItalyDepartment of Surgery, Surgical Oncology Unit, Ospedale Morgagni-Pierantoni, 47121 Forlì, ItalyDepartment of Surgery, Surgical Oncology Unit, Ospedale Morgagni-Pierantoni, 47121 Forlì, ItalyDepartment of Surgery, Surgical Oncology Unit, Ospedale Morgagni-Pierantoni, 47121 Forlì, ItalySurgery Unit, National Cancer Research Centre, Giovanni Paolo II, 70100 Bari, ItalyInterventional Radiology Unit with Integrated Section of Translational Medical Oncology, National Cancer Research Centre, “Giovanni Paolo II”, 70100 Bari, ItalyBackground. Angiogenesis is a complex process involved in both growth and progression of several human and animal tumours. Tryptase is a serin protease stored in mast cells granules, which plays a role in tumour angiogenesis. Mast cells (MCs) can release tryptase following c-Kit receptor (c-KitR) activation. Method. In a series of 25 gastric cancer patients with stage T3N2-3M0 (by AJCC for Gastric Cancer 7th Edition), immunohistochemistry and image analysis methods were employed to evaluate in the tumour tissue the correlation between the number of mast cells positive to tryptase (MCPT), c-KitR expressing cells (c-KitR-EC), and microvascular density (MVD). Results. Data demonstrated a positive correlation between MCPT, c-KitR-EC, and MVD to each other. In tumour tissue the mean number of MCPT was 15, the mean number of c-KitR-EC was 20, and the mean number of MVD was 20. The Pearson test correlating MCPT and MVD, c-KitR-EC and MVD was significantly (r=0.64, P=0.001; r=0.66, P=0.041, resp.). Conclusion. In this pilot study, we suggest that MCPT and c-KitR-EC play a role in gastric cancer angiogenesis, so we think that several c-KitR or tryptase inhibitors such as gabexate mesilate and nafamostat mesilate might be evaluated in clinical trials as a new antiangiogenetic approach.http://dx.doi.org/10.1155/2013/703163 |
| spellingShingle | Michele Ammendola Rosario Sacco Giuseppe Sammarco Giuseppe Donato Valeria Zuccalà Roberto Romano Maria Luposella Rosa Patruno Carlo Vallicelli Giorgio Maria Verdecchia Davide Cavaliere Severino Montemurro Girolamo Ranieri Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated Gastroenterology Research and Practice |
| title | Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated |
| title_full | Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated |
| title_fullStr | Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated |
| title_full_unstemmed | Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated |
| title_short | Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated |
| title_sort | mast cells positive to tryptase and c kit receptor expressing cells correlates with angiogenesis in gastric cancer patients surgically treated |
| url | http://dx.doi.org/10.1155/2013/703163 |
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