Metabolic dysfunction impairs Mycobacterium tuberculosis-specific cytokine and chemokine responses in latent tuberculosis and type 2 diabetes mellitus

Metabolic dysfunction impairs Mycobacterium tuberculosis-specific cytokine and chemokine responses in latent tuberculosis and type 2 diabetes mellitus

Abstract Type 2 diabetes mellitus (DM) is associated with impaired host immune responses, increasing the risk for latent tuberculosis (TB) infection (LTBI). This study investigated how DM and associated metabolic dysfunction alter Mycobacterium tuberculosis (Mtb)-specific cytokine and chemokine resp...

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Bibliographic Details
Main Authors: Phillip Ssekamatte, Diana Sitenda, Rose Nabatanzi, Gyaviira Nkurunungi, Marjorie Nakibuule, Davis Kibirige, Andrew Peter Kyazze, David Patrick Kateete, Bernard Ssentalo Bagaya, Obondo James Sande, Reinout van Crevel, Stephen Cose, Irene Andia Biraro
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Latent tuberculosis infection
Diabetes mellitus
Cytokines
Chemokines
DM control
Dyslipidaemia
Online Access:https://doi.org/10.1038/s41598-025-16385-8
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