Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model
Ovarian cancer (OVCA) mainly disseminates in the peritoneal cavity. Immune functions are important to prevent OVCA progression and recurrence. The mechanism of immunosuppression, a hallmark of tumor progression, is not well understood. The goal of this study was to determine the immune system’s resp...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/6729379 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562837609775104 |
|---|---|
| author | Sa’Rah McNeal Pincas Bitterman Janice M. Bahr Seby L. Edassery Jacques S. Abramowicz Sanjib Basu Animesh Barua |
| author_facet | Sa’Rah McNeal Pincas Bitterman Janice M. Bahr Seby L. Edassery Jacques S. Abramowicz Sanjib Basu Animesh Barua |
| author_sort | Sa’Rah McNeal |
| collection | DOAJ |
| description | Ovarian cancer (OVCA) mainly disseminates in the peritoneal cavity. Immune functions are important to prevent OVCA progression and recurrence. The mechanism of immunosuppression, a hallmark of tumor progression, is not well understood. The goal of this study was to determine the immune system’s responses and its suppression during OVCA development and progression in hens. Frequencies of CD8+ T cells and IgY-containing cells and expression of immunosuppressors including IRG1 and DR6 in OVCA at early and late stages in hens were examined. Frequencies of stromal but not the intratumoral CD+8 T cells and IgY-containing cells increased significantly (P<0.01) during OVCA development and progression. Tumor progression was associated with increased expression of IRG1 and DR6 and decreased infiltration of immune cells into the tumor. Frequency of stromal but not intratumoral immune cells increases during OVCA development and progression. Tumor-induced IRG1 and DR6 may prevent immune cells from invading the tumor. |
| format | Article |
| id | doaj-art-ba5ea07aa4894015af3c05fef9324610 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-ba5ea07aa4894015af3c05fef93246102025-02-03T01:21:37ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/67293796729379Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen ModelSa’Rah McNeal0Pincas Bitterman1Janice M. Bahr2Seby L. Edassery3Jacques S. Abramowicz4Sanjib Basu5Animesh Barua6Rush University Medical Center, Chicago, IL 60612, USARush University Medical Center, Chicago, IL 60612, USAUniversity of Illinois at Urbana-Champaign, Urbana, IL 61801, USARush University Medical Center, Chicago, IL 60612, USAUniversity of Chicago, Chicago, IL 60637, USARush University Medical Center, Chicago, IL 60612, USARush University Medical Center, Chicago, IL 60612, USAOvarian cancer (OVCA) mainly disseminates in the peritoneal cavity. Immune functions are important to prevent OVCA progression and recurrence. The mechanism of immunosuppression, a hallmark of tumor progression, is not well understood. The goal of this study was to determine the immune system’s responses and its suppression during OVCA development and progression in hens. Frequencies of CD8+ T cells and IgY-containing cells and expression of immunosuppressors including IRG1 and DR6 in OVCA at early and late stages in hens were examined. Frequencies of stromal but not the intratumoral CD+8 T cells and IgY-containing cells increased significantly (P<0.01) during OVCA development and progression. Tumor progression was associated with increased expression of IRG1 and DR6 and decreased infiltration of immune cells into the tumor. Frequency of stromal but not intratumoral immune cells increases during OVCA development and progression. Tumor-induced IRG1 and DR6 may prevent immune cells from invading the tumor.http://dx.doi.org/10.1155/2016/6729379 |
| spellingShingle | Sa’Rah McNeal Pincas Bitterman Janice M. Bahr Seby L. Edassery Jacques S. Abramowicz Sanjib Basu Animesh Barua Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model Journal of Immunology Research |
| title | Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model |
| title_full | Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model |
| title_fullStr | Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model |
| title_full_unstemmed | Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model |
| title_short | Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model |
| title_sort | association of immunosuppression with dr6 expression during the development and progression of spontaneous ovarian cancer in laying hen model |
| url | http://dx.doi.org/10.1155/2016/6729379 |
| work_keys_str_mv | AT sarahmcneal associationofimmunosuppressionwithdr6expressionduringthedevelopmentandprogressionofspontaneousovariancancerinlayinghenmodel AT pincasbitterman associationofimmunosuppressionwithdr6expressionduringthedevelopmentandprogressionofspontaneousovariancancerinlayinghenmodel AT janicembahr associationofimmunosuppressionwithdr6expressionduringthedevelopmentandprogressionofspontaneousovariancancerinlayinghenmodel AT sebyledassery associationofimmunosuppressionwithdr6expressionduringthedevelopmentandprogressionofspontaneousovariancancerinlayinghenmodel AT jacquessabramowicz associationofimmunosuppressionwithdr6expressionduringthedevelopmentandprogressionofspontaneousovariancancerinlayinghenmodel AT sanjibbasu associationofimmunosuppressionwithdr6expressionduringthedevelopmentandprogressionofspontaneousovariancancerinlayinghenmodel AT animeshbarua associationofimmunosuppressionwithdr6expressionduringthedevelopmentandprogressionofspontaneousovariancancerinlayinghenmodel |