Cytokines in the Progression of Pancreatic β-Cell Dysfunction
The dysfunction of pancreatic β-cell and the reduction in β-cell mass are the decisive events in the progression of type 2 diabetes. There is increasing evidence that cytokines play important roles in the procedure of β-cell failure. Cytokines, such as IL-1β, IFN-γ, TNF-α, leptin, resistin, adiponec...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2010/515136 |
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| author | Chunjiong Wang Youfei Guan Jichun Yang |
| author_facet | Chunjiong Wang Youfei Guan Jichun Yang |
| author_sort | Chunjiong Wang |
| collection | DOAJ |
| description | The dysfunction of pancreatic β-cell and the reduction in β-cell mass are the decisive events in the progression of type 2 diabetes. There is increasing evidence that cytokines play important roles in the procedure of β-cell failure. Cytokines, such as IL-1β, IFN-γ, TNF-α, leptin, resistin, adiponectin, and visfatin, have been shown to diversely regulate pancreatic β-cell function. Recently, islet-derived cytokine PANcreatic DERived factor (PANDER or FAM3B) has also been demonstrated to be a regulator of islet β-cell function. The change in cytokine profile in islet and plasma is associated with pancreatic β-cell dysfunction and apoptosis. In this paper, we summarize and discuss the recent studies on the effects of certain important cytokines on pancreatic β-cell function. The imbalance in deleterious and protective cytokines plays pivotal roles in the development and progression of pancreatic β-cell dysfunction under insulin-resistant conditions. |
| format | Article |
| id | doaj-art-ba5e52f648bf41959315e4ae013753d2 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ba5e52f648bf41959315e4ae013753d22025-02-03T06:08:31ZengWileyInternational Journal of Endocrinology1687-83371687-83452010-01-01201010.1155/2010/515136515136Cytokines in the Progression of Pancreatic β-Cell DysfunctionChunjiong Wang0Youfei Guan1Jichun Yang2Department of Physiology and Pathophysiology, Peking University Diabetes Center, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Physiology and Pathophysiology, Peking University Diabetes Center, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Physiology and Pathophysiology, Peking University Diabetes Center, Peking University Health Science Center, Beijing 100191, ChinaThe dysfunction of pancreatic β-cell and the reduction in β-cell mass are the decisive events in the progression of type 2 diabetes. There is increasing evidence that cytokines play important roles in the procedure of β-cell failure. Cytokines, such as IL-1β, IFN-γ, TNF-α, leptin, resistin, adiponectin, and visfatin, have been shown to diversely regulate pancreatic β-cell function. Recently, islet-derived cytokine PANcreatic DERived factor (PANDER or FAM3B) has also been demonstrated to be a regulator of islet β-cell function. The change in cytokine profile in islet and plasma is associated with pancreatic β-cell dysfunction and apoptosis. In this paper, we summarize and discuss the recent studies on the effects of certain important cytokines on pancreatic β-cell function. The imbalance in deleterious and protective cytokines plays pivotal roles in the development and progression of pancreatic β-cell dysfunction under insulin-resistant conditions.http://dx.doi.org/10.1155/2010/515136 |
| spellingShingle | Chunjiong Wang Youfei Guan Jichun Yang Cytokines in the Progression of Pancreatic β-Cell Dysfunction International Journal of Endocrinology |
| title | Cytokines in the Progression of Pancreatic β-Cell Dysfunction |
| title_full | Cytokines in the Progression of Pancreatic β-Cell Dysfunction |
| title_fullStr | Cytokines in the Progression of Pancreatic β-Cell Dysfunction |
| title_full_unstemmed | Cytokines in the Progression of Pancreatic β-Cell Dysfunction |
| title_short | Cytokines in the Progression of Pancreatic β-Cell Dysfunction |
| title_sort | cytokines in the progression of pancreatic β cell dysfunction |
| url | http://dx.doi.org/10.1155/2010/515136 |
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