Active Pedicle Epithelial Flap Transposition Combined with Amniotic Membrane Transplantation for Treatment of Nonhealing Corneal Ulcers
Introduction. The objective was to evaluate the efficacy of active pedicle epithelial flap transposition combined with amniotic membrane transplantation (AMT) in treating nonhealing corneal ulcers. Material and Methods. Eleven patients (11 eyes) with nonhealing corneal ulcer who underwent the combin...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/5742346 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552385559396352 |
|---|---|
| author | Ting Zhang Yuexin Wang Yanni Jia Dongle Liu Suxia Li Weiyun Shi Hua Gao |
| author_facet | Ting Zhang Yuexin Wang Yanni Jia Dongle Liu Suxia Li Weiyun Shi Hua Gao |
| author_sort | Ting Zhang |
| collection | DOAJ |
| description | Introduction. The objective was to evaluate the efficacy of active pedicle epithelial flap transposition combined with amniotic membrane transplantation (AMT) in treating nonhealing corneal ulcers. Material and Methods. Eleven patients (11 eyes) with nonhealing corneal ulcer who underwent the combined surgery were included. Postoperatively, ulcer healing time was detected by corneal fluorescein staining. Visual acuity, intraocular pressure, surgical complications, and recurrence were recorded. Corneal status was inspected by the laser scanning confocal microscopy and anterior segment optical coherence tomography (AS-OCT). Results. The primary diseases were herpes simplex keratitis (8 eyes), corneal graft ulcer (2 eyes), and Stevens-Johnson syndrome (1 eye). All epithelial flaps were intact following surgery, without shedding or displacement. Mean ulcer healing time was 10.8±3.1 days, with a healing rate of 91%. Vision significantly improved from 1.70 to 0.82 log MAR (P=0.001). A significant decrease in inflammatory cell infiltration and corneal stromal edema was revealed 2 months postoperatively by confocal microscopy and AS-OCT. Corneal ulcer recurred in 1 eye. None of the patients developed major complications. Conclusion. Active pedicle epithelial flap transposition combined with AMT is a simple and effective treatment for nonhealing corneal ulcers. |
| format | Article |
| id | doaj-art-ba5bd87958964b218947f6919ca6b0aa |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-ba5bd87958964b218947f6919ca6b0aa2025-02-03T05:58:49ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/57423465742346Active Pedicle Epithelial Flap Transposition Combined with Amniotic Membrane Transplantation for Treatment of Nonhealing Corneal UlcersTing Zhang0Yuexin Wang1Yanni Jia2Dongle Liu3Suxia Li4Weiyun Shi5Hua Gao6Qingdao University, 308 Ningxia Road, Qingdao 266071, ChinaShandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, 372 Jingsi Road, Jinan 250021, ChinaQingdao University, 308 Ningxia Road, Qingdao 266071, ChinaShandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, 372 Jingsi Road, Jinan 250021, ChinaShandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, 372 Jingsi Road, Jinan 250021, ChinaShandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, 372 Jingsi Road, Jinan 250021, ChinaShandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, 372 Jingsi Road, Jinan 250021, ChinaIntroduction. The objective was to evaluate the efficacy of active pedicle epithelial flap transposition combined with amniotic membrane transplantation (AMT) in treating nonhealing corneal ulcers. Material and Methods. Eleven patients (11 eyes) with nonhealing corneal ulcer who underwent the combined surgery were included. Postoperatively, ulcer healing time was detected by corneal fluorescein staining. Visual acuity, intraocular pressure, surgical complications, and recurrence were recorded. Corneal status was inspected by the laser scanning confocal microscopy and anterior segment optical coherence tomography (AS-OCT). Results. The primary diseases were herpes simplex keratitis (8 eyes), corneal graft ulcer (2 eyes), and Stevens-Johnson syndrome (1 eye). All epithelial flaps were intact following surgery, without shedding or displacement. Mean ulcer healing time was 10.8±3.1 days, with a healing rate of 91%. Vision significantly improved from 1.70 to 0.82 log MAR (P=0.001). A significant decrease in inflammatory cell infiltration and corneal stromal edema was revealed 2 months postoperatively by confocal microscopy and AS-OCT. Corneal ulcer recurred in 1 eye. None of the patients developed major complications. Conclusion. Active pedicle epithelial flap transposition combined with AMT is a simple and effective treatment for nonhealing corneal ulcers.http://dx.doi.org/10.1155/2016/5742346 |
| spellingShingle | Ting Zhang Yuexin Wang Yanni Jia Dongle Liu Suxia Li Weiyun Shi Hua Gao Active Pedicle Epithelial Flap Transposition Combined with Amniotic Membrane Transplantation for Treatment of Nonhealing Corneal Ulcers Journal of Ophthalmology |
| title | Active Pedicle Epithelial Flap Transposition Combined with Amniotic Membrane Transplantation for Treatment of Nonhealing Corneal Ulcers |
| title_full | Active Pedicle Epithelial Flap Transposition Combined with Amniotic Membrane Transplantation for Treatment of Nonhealing Corneal Ulcers |
| title_fullStr | Active Pedicle Epithelial Flap Transposition Combined with Amniotic Membrane Transplantation for Treatment of Nonhealing Corneal Ulcers |
| title_full_unstemmed | Active Pedicle Epithelial Flap Transposition Combined with Amniotic Membrane Transplantation for Treatment of Nonhealing Corneal Ulcers |
| title_short | Active Pedicle Epithelial Flap Transposition Combined with Amniotic Membrane Transplantation for Treatment of Nonhealing Corneal Ulcers |
| title_sort | active pedicle epithelial flap transposition combined with amniotic membrane transplantation for treatment of nonhealing corneal ulcers |
| url | http://dx.doi.org/10.1155/2016/5742346 |
| work_keys_str_mv | AT tingzhang activepedicleepithelialflaptranspositioncombinedwithamnioticmembranetransplantationfortreatmentofnonhealingcornealulcers AT yuexinwang activepedicleepithelialflaptranspositioncombinedwithamnioticmembranetransplantationfortreatmentofnonhealingcornealulcers AT yannijia activepedicleepithelialflaptranspositioncombinedwithamnioticmembranetransplantationfortreatmentofnonhealingcornealulcers AT dongleliu activepedicleepithelialflaptranspositioncombinedwithamnioticmembranetransplantationfortreatmentofnonhealingcornealulcers AT suxiali activepedicleepithelialflaptranspositioncombinedwithamnioticmembranetransplantationfortreatmentofnonhealingcornealulcers AT weiyunshi activepedicleepithelialflaptranspositioncombinedwithamnioticmembranetransplantationfortreatmentofnonhealingcornealulcers AT huagao activepedicleepithelialflaptranspositioncombinedwithamnioticmembranetransplantationfortreatmentofnonhealingcornealulcers |