Comparison of Adult Hippocampal Neurogenesis and Susceptibility to Treadmill Exercise in Nine Mouse Strains
The genetic background of mice has various influences on the efficacy of physical exercise, as well as adult neurogenesis in the hippocampus. In this study, we investigated the basal level of hippocampal neurogenesis, as well as the effects of treadmill exercise on adult hippocampal neurogenesis in...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/5863258 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556122751369216 |
|---|---|
| author | Jong Whi Kim Sung Min Nam Dae Young Yoo Hyo Young Jung Il Yong Kim In Koo Hwang Je Kyung Seong Yeo Sung Yoon |
| author_facet | Jong Whi Kim Sung Min Nam Dae Young Yoo Hyo Young Jung Il Yong Kim In Koo Hwang Je Kyung Seong Yeo Sung Yoon |
| author_sort | Jong Whi Kim |
| collection | DOAJ |
| description | The genetic background of mice has various influences on the efficacy of physical exercise, as well as adult neurogenesis in the hippocampus. In this study, we investigated the basal level of hippocampal neurogenesis, as well as the effects of treadmill exercise on adult hippocampal neurogenesis in 9 mouse strains: 8 very commonly used laboratory inbred mouse strains (C57BL/6, BALB/c, A/J, C3H/HeJ, DBA/1, DBA/2, 129/SvJ, and FVB) and 1 outbred mouse strain (ICR). All 9 strains showed diverse basal levels of cell proliferation, neuroblast differentiation, and integration into granule cells in the sedentary group. C57BL/6 mice showed the highest levels of cell proliferation, neuroblast differentiation, and integration into granule cells at basal levels, and the DBA/2 mice showed the lowest levels. The efficacy of integration into granule cells was maximal in ICR mice. Treadmill exercise increased adult hippocampal neurogenesis in all 9 mouse strains. These results suggest that the genetic background of mice affects hippocampal neurogenesis and C57BL/6 mice are the most useful strain to assess basal levels of cell proliferation and neuroblast differentiation, but not maturation into granule cells. In addition, the DBA/2 strain is not suitable for studying hippocampal neurogenesis. |
| format | Article |
| id | doaj-art-ba535773217548db834e2f582ea08a06 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-ba535773217548db834e2f582ea08a062025-02-03T05:46:20ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/58632585863258Comparison of Adult Hippocampal Neurogenesis and Susceptibility to Treadmill Exercise in Nine Mouse StrainsJong Whi Kim0Sung Min Nam1Dae Young Yoo2Hyo Young Jung3Il Yong Kim4In Koo Hwang5Je Kyung Seong6Yeo Sung Yoon7Department of Anatomy and Cell Biology, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of KoreaDepartment of Anatomy and Cell Biology, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of KoreaDepartment of Anatomy and Cell Biology, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of KoreaDepartment of Anatomy and Cell Biology, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of KoreaKMPC (Korea Mouse Phenotyping Center), Seoul National University, Seoul 08826, Republic of KoreaDepartment of Anatomy and Cell Biology, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of KoreaDepartment of Anatomy and Cell Biology, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of KoreaDepartment of Anatomy and Cell Biology, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of KoreaThe genetic background of mice has various influences on the efficacy of physical exercise, as well as adult neurogenesis in the hippocampus. In this study, we investigated the basal level of hippocampal neurogenesis, as well as the effects of treadmill exercise on adult hippocampal neurogenesis in 9 mouse strains: 8 very commonly used laboratory inbred mouse strains (C57BL/6, BALB/c, A/J, C3H/HeJ, DBA/1, DBA/2, 129/SvJ, and FVB) and 1 outbred mouse strain (ICR). All 9 strains showed diverse basal levels of cell proliferation, neuroblast differentiation, and integration into granule cells in the sedentary group. C57BL/6 mice showed the highest levels of cell proliferation, neuroblast differentiation, and integration into granule cells at basal levels, and the DBA/2 mice showed the lowest levels. The efficacy of integration into granule cells was maximal in ICR mice. Treadmill exercise increased adult hippocampal neurogenesis in all 9 mouse strains. These results suggest that the genetic background of mice affects hippocampal neurogenesis and C57BL/6 mice are the most useful strain to assess basal levels of cell proliferation and neuroblast differentiation, but not maturation into granule cells. In addition, the DBA/2 strain is not suitable for studying hippocampal neurogenesis.http://dx.doi.org/10.1155/2017/5863258 |
| spellingShingle | Jong Whi Kim Sung Min Nam Dae Young Yoo Hyo Young Jung Il Yong Kim In Koo Hwang Je Kyung Seong Yeo Sung Yoon Comparison of Adult Hippocampal Neurogenesis and Susceptibility to Treadmill Exercise in Nine Mouse Strains Neural Plasticity |
| title | Comparison of Adult Hippocampal Neurogenesis and Susceptibility to Treadmill Exercise in Nine Mouse Strains |
| title_full | Comparison of Adult Hippocampal Neurogenesis and Susceptibility to Treadmill Exercise in Nine Mouse Strains |
| title_fullStr | Comparison of Adult Hippocampal Neurogenesis and Susceptibility to Treadmill Exercise in Nine Mouse Strains |
| title_full_unstemmed | Comparison of Adult Hippocampal Neurogenesis and Susceptibility to Treadmill Exercise in Nine Mouse Strains |
| title_short | Comparison of Adult Hippocampal Neurogenesis and Susceptibility to Treadmill Exercise in Nine Mouse Strains |
| title_sort | comparison of adult hippocampal neurogenesis and susceptibility to treadmill exercise in nine mouse strains |
| url | http://dx.doi.org/10.1155/2017/5863258 |
| work_keys_str_mv | AT jongwhikim comparisonofadulthippocampalneurogenesisandsusceptibilitytotreadmillexerciseinninemousestrains AT sungminnam comparisonofadulthippocampalneurogenesisandsusceptibilitytotreadmillexerciseinninemousestrains AT daeyoungyoo comparisonofadulthippocampalneurogenesisandsusceptibilitytotreadmillexerciseinninemousestrains AT hyoyoungjung comparisonofadulthippocampalneurogenesisandsusceptibilitytotreadmillexerciseinninemousestrains AT ilyongkim comparisonofadulthippocampalneurogenesisandsusceptibilitytotreadmillexerciseinninemousestrains AT inkoohwang comparisonofadulthippocampalneurogenesisandsusceptibilitytotreadmillexerciseinninemousestrains AT jekyungseong comparisonofadulthippocampalneurogenesisandsusceptibilitytotreadmillexerciseinninemousestrains AT yeosungyoon comparisonofadulthippocampalneurogenesisandsusceptibilitytotreadmillexerciseinninemousestrains |