Determination of Tobramycin in M9 Medium by LC-MS/MS: Signal Enhancement by Trichloroacetic Acid

Determination of Tobramycin in M9 Medium by LC-MS/MS: Signal Enhancement by Trichloroacetic Acid

It is well known that ion-pairing reagents cause ion suppression in LC-MS/MS methods. Here, we report that trichloroacetic acid increases the MS signal of tobramycin. To support studies of an in vitro pharmacokinetic/pharmacodynamic simulator for bacterial biofilms, an LC-MS/MS method for determinat...

Full description

Saved in:
Bibliographic Details
Main Authors: Liusheng Huang, Janus Anders Juul Haagensen, Davide Verotta, Vincent Cheah, Alfred M. Spormann, Francesca Aweeka, Katherine Yang
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Journal of Analytical Methods in Chemistry
Online Access:http://dx.doi.org/10.1155/2018/7965124
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items