Homocysteine enhances the excitability of cultured hippocampal neurons without altering the gene expression of voltage-gated ion channels

Homocysteine enhances the excitability of cultured hippocampal neurons without altering the gene expression of voltage-gated ion channels

Abstract Elevated plasma homocysteine (Hcy) levels lead to hyperhomocysteinemia, a condition associated with various neurological disorders affecting multiple brain regions, including the hippocampus. In this study, we investigated the effects of exposing cultured rat hippocampal neurons to Hcy conc...

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Main Authors: Alzbeta Filipova, Matus Tomko, Katarina Ondacova, Lucia Dubiel-Hoppanova, Nikola Chmúrčiaková, Leoš Cmarko, Robin N. Stringer, Norbert Weiss, Lubica Lacinova
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Molecular Brain
Subjects:
Hyperhomocysteinemia
Hippocampal excitability
Transcriptomics
Voltage gated ion channels
Intracellular calcium
Online Access:https://doi.org/10.1186/s13041-025-01205-x
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