Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful?
Survivin, an antiapoptotic molecule from inhibitor of apoptosis protein (IAP) family, is most known for its implication in cancer as there are some efforts to apply it for diagnostic as well as therapeutic purposes in oncology. On the other hand, it could be a useful molecule to be positively target...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2018/6492034 |
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| _version_ | 1832568383066865664 |
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| author | Sara Assadiasl Mohammad Javad Mousavi Aliakbar Amirzargar |
| author_facet | Sara Assadiasl Mohammad Javad Mousavi Aliakbar Amirzargar |
| author_sort | Sara Assadiasl |
| collection | DOAJ |
| description | Survivin, an antiapoptotic molecule from inhibitor of apoptosis protein (IAP) family, is most known for its implication in cancer as there are some efforts to apply it for diagnostic as well as therapeutic purposes in oncology. On the other hand, it could be a useful molecule to be positively targeted when trying to save tissue and promote cells viability. Since protecting the allograft from ischemia reperfusion injury and inflammation-induced damage is a considerable objective in transplantation, it is reasonable to take advantage from antiapoptotic agents like survivin in order to achieve this goal. However, survivin’s potential ability to induce malignancies makes some concerns about its use in clinic. The other barrier is this molecule’s involvement in lymphocytes development and proliferation which might increase the risk of graft rejection due to adaptive immune system overactivation. In this review we summarize the few studies carried out about survivin’s effect on graft survival and probable advantages and disadvantages of its overexpression in transplantation. |
| format | Article |
| id | doaj-art-ba35eb3e3150439c9b53dc1830bbd649 |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-ba35eb3e3150439c9b53dc1830bbd6492025-02-03T00:59:16ZengWileyJournal of Transplantation2090-00072090-00152018-01-01201810.1155/2018/64920346492034Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful?Sara Assadiasl0Mohammad Javad Mousavi1Aliakbar Amirzargar2Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, IranMolecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, IranSurvivin, an antiapoptotic molecule from inhibitor of apoptosis protein (IAP) family, is most known for its implication in cancer as there are some efforts to apply it for diagnostic as well as therapeutic purposes in oncology. On the other hand, it could be a useful molecule to be positively targeted when trying to save tissue and promote cells viability. Since protecting the allograft from ischemia reperfusion injury and inflammation-induced damage is a considerable objective in transplantation, it is reasonable to take advantage from antiapoptotic agents like survivin in order to achieve this goal. However, survivin’s potential ability to induce malignancies makes some concerns about its use in clinic. The other barrier is this molecule’s involvement in lymphocytes development and proliferation which might increase the risk of graft rejection due to adaptive immune system overactivation. In this review we summarize the few studies carried out about survivin’s effect on graft survival and probable advantages and disadvantages of its overexpression in transplantation.http://dx.doi.org/10.1155/2018/6492034 |
| spellingShingle | Sara Assadiasl Mohammad Javad Mousavi Aliakbar Amirzargar Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful? Journal of Transplantation |
| title | Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful? |
| title_full | Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful? |
| title_fullStr | Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful? |
| title_full_unstemmed | Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful? |
| title_short | Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful? |
| title_sort | antiapoptotic molecule survivin in transplantation helpful or harmful |
| url | http://dx.doi.org/10.1155/2018/6492034 |
| work_keys_str_mv | AT saraassadiasl antiapoptoticmoleculesurvivinintransplantationhelpfulorharmful AT mohammadjavadmousavi antiapoptoticmoleculesurvivinintransplantationhelpfulorharmful AT aliakbaramirzargar antiapoptoticmoleculesurvivinintransplantationhelpfulorharmful |