Personalized Management in Low-Risk Prostate Cancer: The Role of Biomarkers
Current criteria to predict low-risk prostate cancer (PCa) are still subject to discussion as a substantial number of PCa patients who progress to a more aggressive disease seem to be missed, using these criteria. The main challenge in PCa diagnosis, therefore, is to distinguish patients with low-ri...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/327104 |
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| author | Siebren Dijkstra Agus Rizal A. H. Hamid Gisèle H. J. M. Leyten Jack A. Schalken |
| author_facet | Siebren Dijkstra Agus Rizal A. H. Hamid Gisèle H. J. M. Leyten Jack A. Schalken |
| author_sort | Siebren Dijkstra |
| collection | DOAJ |
| description | Current criteria to predict low-risk prostate cancer (PCa) are still subject to discussion as a substantial number of PCa patients who progress to a more aggressive disease seem to be missed, using these criteria. The main challenge in PCa diagnosis, therefore, is to distinguish patients with low-risk PCa who will show slow progression of disease from patients at risk for progression to a more aggressive cancer. The current discovered biomarkers could potentially guide in this management and improve detection, staging, and prognosis. This paper provides an overview of the current available serum-, urine-, and tissue-based biomarkers in PCa and evaluates the clinical usefulness of these biomarkers in the detection and management of low-risk PCa. |
| format | Article |
| id | doaj-art-ba30c380f20a4c6bb502b2dce5d3ee2f |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-ba30c380f20a4c6bb502b2dce5d3ee2f2025-02-03T06:13:09ZengWileyProstate Cancer2090-31112090-312X2012-01-01201210.1155/2012/327104327104Personalized Management in Low-Risk Prostate Cancer: The Role of BiomarkersSiebren Dijkstra0Agus Rizal A. H. Hamid1Gisèle H. J. M. Leyten2Jack A. Schalken3Department of Urology, Radboud University Nijmegen Medical Centre, Geert-Grooteplein Zuid 10, P.O. Box 9101, 6500 HB Nijmegen, The NetherlandsDepartment of Urology, Radboud University Nijmegen Medical Centre, Geert-Grooteplein Zuid 10, P.O. Box 9101, 6500 HB Nijmegen, The NetherlandsDepartment of Urology, Radboud University Nijmegen Medical Centre, Geert-Grooteplein Zuid 10, P.O. Box 9101, 6500 HB Nijmegen, The NetherlandsDepartment of Urology, Radboud University Nijmegen Medical Centre, Geert-Grooteplein Zuid 10, P.O. Box 9101, 6500 HB Nijmegen, The NetherlandsCurrent criteria to predict low-risk prostate cancer (PCa) are still subject to discussion as a substantial number of PCa patients who progress to a more aggressive disease seem to be missed, using these criteria. The main challenge in PCa diagnosis, therefore, is to distinguish patients with low-risk PCa who will show slow progression of disease from patients at risk for progression to a more aggressive cancer. The current discovered biomarkers could potentially guide in this management and improve detection, staging, and prognosis. This paper provides an overview of the current available serum-, urine-, and tissue-based biomarkers in PCa and evaluates the clinical usefulness of these biomarkers in the detection and management of low-risk PCa.http://dx.doi.org/10.1155/2012/327104 |
| spellingShingle | Siebren Dijkstra Agus Rizal A. H. Hamid Gisèle H. J. M. Leyten Jack A. Schalken Personalized Management in Low-Risk Prostate Cancer: The Role of Biomarkers Prostate Cancer |
| title | Personalized Management in Low-Risk Prostate Cancer: The Role of Biomarkers |
| title_full | Personalized Management in Low-Risk Prostate Cancer: The Role of Biomarkers |
| title_fullStr | Personalized Management in Low-Risk Prostate Cancer: The Role of Biomarkers |
| title_full_unstemmed | Personalized Management in Low-Risk Prostate Cancer: The Role of Biomarkers |
| title_short | Personalized Management in Low-Risk Prostate Cancer: The Role of Biomarkers |
| title_sort | personalized management in low risk prostate cancer the role of biomarkers |
| url | http://dx.doi.org/10.1155/2012/327104 |
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