Feasibility and potential diagnostic value of [18F]PI-2620 PET in patients with down syndrome and Alzheimer’s disease: a case series

Feasibility and potential diagnostic value of [18F]PI-2620 PET in patients with down syndrome and Alzheimer’s disease: a case series

Purpose of the reportAdults with Down Syndrome (DS) have a substantially increased risk for Alzheimer’s disease (AD) due to the triplicated amyloid-precursor-protein gene on chromosome 21, resulting in amyloid and tau accumulation. However, tau PET assessments are not sufficiently implemented in DS-...

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Bibliographic Details
Main Authors: Olivia Wagemann, Matthias Brendel, Nicolai Franzmeier, Georg Nübling, Johannes Gnörich, Mirlind Zaganjori, Catharina Prix, Anna Stockbauer, Elisabeth Wlasich, Sandra V. Loosli, Katja Sandkühler, Lukas Frontzkowski, Günter Höglinger, Johannes Levin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Neuroscience
Subjects:
down syndrome
Alzheimer
tau PET
18F-PI-2620
case series
trisomy 21
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1505999/full
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