The Plasma Soluble Urokinase Plasminogen Activator Receptor Is Related to Disease Activity of Patients with ANCA-Associated Vasculitis
Objective. The soluble urokinase plasminogen activator receptor (suPAR) is associated with kidney diseases and is used as a prognostic factor of renal function progression. The aim of this study was to explore whether circulating suPAR was associated with antineutrophil cytoplasmic autoantibody- (AN...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/7850179 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566018871918592 |
|---|---|
| author | Fei Huang Yueqiang Li Ranran Xu Anying Cheng Yongman Lv Qingquan Liu |
| author_facet | Fei Huang Yueqiang Li Ranran Xu Anying Cheng Yongman Lv Qingquan Liu |
| author_sort | Fei Huang |
| collection | DOAJ |
| description | Objective. The soluble urokinase plasminogen activator receptor (suPAR) is associated with kidney diseases and is used as a prognostic factor of renal function progression. The aim of this study was to explore whether circulating suPAR was associated with antineutrophil cytoplasmic autoantibody- (ANCA-) associated vasculitis (AAV) disease activity. Methods. We evaluated 90 AAV patients with follow-up data and 35 normal controls; their plasma suPAR and C-reactive protein (CRP) levels were measured by ELISA. Associations between these levels, clinical parameters, and prognosis were analyzed. Results. Plasma suPAR levels in AAV patients were significantly higher than in healthy controls (5,920.08±3,447.17 vs. 1,441.97±835.04 pg/mL, P<0.001). Furthermore, suPAR was significantly elevated in AAV patients in active stage compared to those in partial remissions (6,492.19±3,689.48 vs. 5,031.86±2,489.01 pg/mL, P=0.039). Correlation analyses demonstrated that suPAR levels positively correlated with initial serum creatinine, BVAS, CRP, and procalcitonin concentration, and negatively correlated with eGFR and C3 circulating levels. In a Kaplan-Meier survival analysis, patients with plasma suPAR levels >5683.3 pg/mL showed poorer survival than patients with lower levels (log-rank, P=0.001). Besides, multivariate analyses confirmed that plasma suPAR levels were an independent adverse prognostic factor for a composite outcome of end-stage renal disease (ESRD) or death, after adjusting for age and gender (HR 1.05, 95% CI=1.01−1.11, P=0.043). Receiver operating characteristic curves showed a suPAR cutoff value >6662.2 pg/mL for composite outcome with 68% sensitivity and 88% specificity, with an AUC=0.82, (95% CI=0.68−0.96, P<0.001). Conclusion. Circulating suPAR levels might be a marker of activity correlated with disease activity in AAV patients, and, to some extent, could be a factor of poor prognosis. |
| format | Article |
| id | doaj-art-ba2c0a724d5e413f88902e1b54f8ff95 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ba2c0a724d5e413f88902e1b54f8ff952025-02-03T01:05:23ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/78501797850179The Plasma Soluble Urokinase Plasminogen Activator Receptor Is Related to Disease Activity of Patients with ANCA-Associated VasculitisFei Huang0Yueqiang Li1Ranran Xu2Anying Cheng3Yongman Lv4Qingquan Liu5Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaObjective. The soluble urokinase plasminogen activator receptor (suPAR) is associated with kidney diseases and is used as a prognostic factor of renal function progression. The aim of this study was to explore whether circulating suPAR was associated with antineutrophil cytoplasmic autoantibody- (ANCA-) associated vasculitis (AAV) disease activity. Methods. We evaluated 90 AAV patients with follow-up data and 35 normal controls; their plasma suPAR and C-reactive protein (CRP) levels were measured by ELISA. Associations between these levels, clinical parameters, and prognosis were analyzed. Results. Plasma suPAR levels in AAV patients were significantly higher than in healthy controls (5,920.08±3,447.17 vs. 1,441.97±835.04 pg/mL, P<0.001). Furthermore, suPAR was significantly elevated in AAV patients in active stage compared to those in partial remissions (6,492.19±3,689.48 vs. 5,031.86±2,489.01 pg/mL, P=0.039). Correlation analyses demonstrated that suPAR levels positively correlated with initial serum creatinine, BVAS, CRP, and procalcitonin concentration, and negatively correlated with eGFR and C3 circulating levels. In a Kaplan-Meier survival analysis, patients with plasma suPAR levels >5683.3 pg/mL showed poorer survival than patients with lower levels (log-rank, P=0.001). Besides, multivariate analyses confirmed that plasma suPAR levels were an independent adverse prognostic factor for a composite outcome of end-stage renal disease (ESRD) or death, after adjusting for age and gender (HR 1.05, 95% CI=1.01−1.11, P=0.043). Receiver operating characteristic curves showed a suPAR cutoff value >6662.2 pg/mL for composite outcome with 68% sensitivity and 88% specificity, with an AUC=0.82, (95% CI=0.68−0.96, P<0.001). Conclusion. Circulating suPAR levels might be a marker of activity correlated with disease activity in AAV patients, and, to some extent, could be a factor of poor prognosis.http://dx.doi.org/10.1155/2020/7850179 |
| spellingShingle | Fei Huang Yueqiang Li Ranran Xu Anying Cheng Yongman Lv Qingquan Liu The Plasma Soluble Urokinase Plasminogen Activator Receptor Is Related to Disease Activity of Patients with ANCA-Associated Vasculitis Mediators of Inflammation |
| title | The Plasma Soluble Urokinase Plasminogen Activator Receptor Is Related to Disease Activity of Patients with ANCA-Associated Vasculitis |
| title_full | The Plasma Soluble Urokinase Plasminogen Activator Receptor Is Related to Disease Activity of Patients with ANCA-Associated Vasculitis |
| title_fullStr | The Plasma Soluble Urokinase Plasminogen Activator Receptor Is Related to Disease Activity of Patients with ANCA-Associated Vasculitis |
| title_full_unstemmed | The Plasma Soluble Urokinase Plasminogen Activator Receptor Is Related to Disease Activity of Patients with ANCA-Associated Vasculitis |
| title_short | The Plasma Soluble Urokinase Plasminogen Activator Receptor Is Related to Disease Activity of Patients with ANCA-Associated Vasculitis |
| title_sort | plasma soluble urokinase plasminogen activator receptor is related to disease activity of patients with anca associated vasculitis |
| url | http://dx.doi.org/10.1155/2020/7850179 |
| work_keys_str_mv | AT feihuang theplasmasolubleurokinaseplasminogenactivatorreceptorisrelatedtodiseaseactivityofpatientswithancaassociatedvasculitis AT yueqiangli theplasmasolubleurokinaseplasminogenactivatorreceptorisrelatedtodiseaseactivityofpatientswithancaassociatedvasculitis AT ranranxu theplasmasolubleurokinaseplasminogenactivatorreceptorisrelatedtodiseaseactivityofpatientswithancaassociatedvasculitis AT anyingcheng theplasmasolubleurokinaseplasminogenactivatorreceptorisrelatedtodiseaseactivityofpatientswithancaassociatedvasculitis AT yongmanlv theplasmasolubleurokinaseplasminogenactivatorreceptorisrelatedtodiseaseactivityofpatientswithancaassociatedvasculitis AT qingquanliu theplasmasolubleurokinaseplasminogenactivatorreceptorisrelatedtodiseaseactivityofpatientswithancaassociatedvasculitis AT feihuang plasmasolubleurokinaseplasminogenactivatorreceptorisrelatedtodiseaseactivityofpatientswithancaassociatedvasculitis AT yueqiangli plasmasolubleurokinaseplasminogenactivatorreceptorisrelatedtodiseaseactivityofpatientswithancaassociatedvasculitis AT ranranxu plasmasolubleurokinaseplasminogenactivatorreceptorisrelatedtodiseaseactivityofpatientswithancaassociatedvasculitis AT anyingcheng plasmasolubleurokinaseplasminogenactivatorreceptorisrelatedtodiseaseactivityofpatientswithancaassociatedvasculitis AT yongmanlv plasmasolubleurokinaseplasminogenactivatorreceptorisrelatedtodiseaseactivityofpatientswithancaassociatedvasculitis AT qingquanliu plasmasolubleurokinaseplasminogenactivatorreceptorisrelatedtodiseaseactivityofpatientswithancaassociatedvasculitis |