Co-Expression of Plexin-B1 and Met in Human Breast and Ovary Tumours Enhances the Risk of Progression
Background: Plex-B1, the receptor of Sema4D, has been implicated in tumour growth, angiogenesis and metastasis. The binding of Sema4D to Plex-B1 can trigger the activation of Met tyrosine kinase, thereby promoting cell dissociation and invasive growth. We tested the hypothesis that the expression of...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2009-0504 |
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| _version_ | 1832567124566999040 |
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| author | Guido Valente Giuseppina Nicotra Marisa Arrondini Roberta Castino Lorena Capparuccia Maria Prat Simonetta Kerim Luca Tamagnone Ciro Isidoro |
| author_facet | Guido Valente Giuseppina Nicotra Marisa Arrondini Roberta Castino Lorena Capparuccia Maria Prat Simonetta Kerim Luca Tamagnone Ciro Isidoro |
| author_sort | Guido Valente |
| collection | DOAJ |
| description | Background: Plex-B1, the receptor of Sema4D, has been implicated in tumour growth, angiogenesis and metastasis. The binding of Sema4D to Plex-B1 can trigger the activation of Met tyrosine kinase, thereby promoting cell dissociation and invasive growth. We tested the hypothesis that the expression of Plex-B1, either alone or in association with Met, can be of predictive value for tumour progression. |
| format | Article |
| id | doaj-art-b9fddebf395240dbb029e2c61bebe8b8 |
| institution | Kabale University |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-b9fddebf395240dbb029e2c61bebe8b82025-02-03T01:02:19ZengWileyCellular Oncology1570-58701875-86062009-01-0131642343610.3233/CLO-2009-0504Co-Expression of Plexin-B1 and Met in Human Breast and Ovary Tumours Enhances the Risk of ProgressionGuido Valente0Giuseppina Nicotra1Marisa Arrondini2Roberta Castino3Lorena Capparuccia4Maria Prat5Simonetta Kerim6Luca Tamagnone7Ciro Isidoro8Pathology Section, Department of Clinical and Experimental Medicine, Amedeo Avogadro University, Novara, ItalyPathology Section, Department of Clinical and Experimental Medicine, Amedeo Avogadro University, Novara, ItalyPathology Section, Department of Clinical and Experimental Medicine, Amedeo Avogadro University, Novara, ItalyLaboratory of Molecular Pathology, Department of Medical Sciences, Amedeo Avogadro University, Novara, ItalyInstitute for Cancer Research and Treatment (IRCC), University of Torino Medical School, Candiolo (TO), ItalyLaboratory of Histology, Department of Medical Sciences, Amedeo Avogadro University, Novara, ItalyCytogenetics Unit, Department of Laboratory Diagnostics, San Giovanni Hospital, Torino, ItalyCytogenetics Unit, Department of Laboratory Diagnostics, San Giovanni Hospital, Torino, ItalyLaboratory of Molecular Pathology, Department of Medical Sciences, Amedeo Avogadro University, Novara, ItalyBackground: Plex-B1, the receptor of Sema4D, has been implicated in tumour growth, angiogenesis and metastasis. The binding of Sema4D to Plex-B1 can trigger the activation of Met tyrosine kinase, thereby promoting cell dissociation and invasive growth. We tested the hypothesis that the expression of Plex-B1, either alone or in association with Met, can be of predictive value for tumour progression.http://dx.doi.org/10.3233/CLO-2009-0504 |
| spellingShingle | Guido Valente Giuseppina Nicotra Marisa Arrondini Roberta Castino Lorena Capparuccia Maria Prat Simonetta Kerim Luca Tamagnone Ciro Isidoro Co-Expression of Plexin-B1 and Met in Human Breast and Ovary Tumours Enhances the Risk of Progression Cellular Oncology |
| title | Co-Expression of Plexin-B1 and Met in Human Breast and Ovary Tumours Enhances the Risk of Progression |
| title_full | Co-Expression of Plexin-B1 and Met in Human Breast and Ovary Tumours Enhances the Risk of Progression |
| title_fullStr | Co-Expression of Plexin-B1 and Met in Human Breast and Ovary Tumours Enhances the Risk of Progression |
| title_full_unstemmed | Co-Expression of Plexin-B1 and Met in Human Breast and Ovary Tumours Enhances the Risk of Progression |
| title_short | Co-Expression of Plexin-B1 and Met in Human Breast and Ovary Tumours Enhances the Risk of Progression |
| title_sort | co expression of plexin b1 and met in human breast and ovary tumours enhances the risk of progression |
| url | http://dx.doi.org/10.3233/CLO-2009-0504 |
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