In Vitro Studies of Anti-Hemolytic and Cytotoxic Activity of Procyanidin-Rich Extract from the Leaves of Actinidia arguta
The leaves of mini kiwi (Actinidia arguta) are a rich source of phenolic compounds, in particular the B-type procyanidins that exhibit e.g. antioxidant, anticancer, antiviral, and anti-inflammatory activities. The aim of this study was to determine the biological activity of the extract from leaves...
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Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences
2018-06-01
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| Series: | Polish Journal of Food and Nutrition Sciences |
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| Online Access: | http://www.degruyter.com/view/j/pjfns.2018.68.issue-2/pjfns-2017-0021/pjfns-2017-0021.xml?format=INT |
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| author | Cyboran-Mikołajczyk Sylwia Csonka Ákos Molnar Joseph Szabó Diana Oszmiański Jan Kleszczyńska Halina |
| author_facet | Cyboran-Mikołajczyk Sylwia Csonka Ákos Molnar Joseph Szabó Diana Oszmiański Jan Kleszczyńska Halina |
| author_sort | Cyboran-Mikołajczyk Sylwia |
| collection | DOAJ |
| description | The leaves of mini kiwi (Actinidia arguta) are a rich source of phenolic compounds, in particular the B-type procyanidins that exhibit e.g. antioxidant, anticancer, antiviral, and anti-inflammatory activities. The aim of this study was to determine the biological activity of the extract from leaves of kiwi in relation to cells of erythrocytes and lymphoma. This activity was determined by studying kiwi leaves extract anti-hemolytic, cytotoxic and antiproliferative activity, and its ability to change the physical properties of the cell membrane and inhibit multidrug resistance of mouse lymphoma cells. It was shown that the extract ingredients bound to the cells, caused changes in erythrocyte shape and slightly affected the granularity and size of lymphoma cells. They effectively protected the red blood cells from oxidative damage, but were not toxic to lymphoma cells and did not affect their multidrug resistance. The extract of kiwi leaves is an effective antioxidant but it does not exhibit cytotoxic activity. Therefore, it can be used in the prevention of diseases, especially those related to oxidative stress. |
| format | Article |
| id | doaj-art-b9eca7bb2d97463c94a5d2741efb702d |
| institution | Kabale University |
| issn | 2083-6007 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences |
| record_format | Article |
| series | Polish Journal of Food and Nutrition Sciences |
| spelling | doaj-art-b9eca7bb2d97463c94a5d2741efb702d2025-02-02T20:58:10ZengInstitute of Animal Reproduction and Food Research of the Polish Academy of SciencesPolish Journal of Food and Nutrition Sciences2083-60072018-06-0168217117710.1515/pjfns-2017-0021pjfns-2017-0021In Vitro Studies of Anti-Hemolytic and Cytotoxic Activity of Procyanidin-Rich Extract from the Leaves of Actinidia argutaCyboran-Mikołajczyk Sylwia0Csonka Ákos1Molnar Joseph2Szabó Diana3Oszmiański Jan4Kleszczyńska Halina5Department of Physics and Biophysics, Wroclaw University of Environmental and Life Sciences, Norwida 25,50–375 Wrocław, PolandDepartment of Medicinal Microbiology and Immunobiology, University of Szeged, Dóm tér 10, H-6720 Szeged, HungaryDepartment of Medicinal Microbiology and Immunobiology, University of Szeged, Dóm tér 10, H-6720 Szeged, HungaryDepartment of Otorhinolaryngology and Head-Neck Surgery, University of Szeged, Tisza L. krt. 111, H-6725 Szeged, HungaryDepartment of Fruit, Vegetable and Nutraceutical Technology, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, PolandDepartment of Physics and Biophysics, Wroclaw University of Environmental and Life Sciences, Norwida 25,50-375 Wrocław, PolandThe leaves of mini kiwi (Actinidia arguta) are a rich source of phenolic compounds, in particular the B-type procyanidins that exhibit e.g. antioxidant, anticancer, antiviral, and anti-inflammatory activities. The aim of this study was to determine the biological activity of the extract from leaves of kiwi in relation to cells of erythrocytes and lymphoma. This activity was determined by studying kiwi leaves extract anti-hemolytic, cytotoxic and antiproliferative activity, and its ability to change the physical properties of the cell membrane and inhibit multidrug resistance of mouse lymphoma cells. It was shown that the extract ingredients bound to the cells, caused changes in erythrocyte shape and slightly affected the granularity and size of lymphoma cells. They effectively protected the red blood cells from oxidative damage, but were not toxic to lymphoma cells and did not affect their multidrug resistance. The extract of kiwi leaves is an effective antioxidant but it does not exhibit cytotoxic activity. Therefore, it can be used in the prevention of diseases, especially those related to oxidative stress.http://www.degruyter.com/view/j/pjfns.2018.68.issue-2/pjfns-2017-0021/pjfns-2017-0021.xml?format=INTanti-hemolytic activitycytotoxic activityL5178Y cellsmultidrug resistancemini-kiwi (Actinidia arguta) |
| spellingShingle | Cyboran-Mikołajczyk Sylwia Csonka Ákos Molnar Joseph Szabó Diana Oszmiański Jan Kleszczyńska Halina In Vitro Studies of Anti-Hemolytic and Cytotoxic Activity of Procyanidin-Rich Extract from the Leaves of Actinidia arguta Polish Journal of Food and Nutrition Sciences anti-hemolytic activity cytotoxic activity L5178Y cells multidrug resistance mini-kiwi (Actinidia arguta) |
| title | In Vitro Studies of Anti-Hemolytic and Cytotoxic Activity of Procyanidin-Rich Extract from the Leaves of Actinidia arguta |
| title_full | In Vitro Studies of Anti-Hemolytic and Cytotoxic Activity of Procyanidin-Rich Extract from the Leaves of Actinidia arguta |
| title_fullStr | In Vitro Studies of Anti-Hemolytic and Cytotoxic Activity of Procyanidin-Rich Extract from the Leaves of Actinidia arguta |
| title_full_unstemmed | In Vitro Studies of Anti-Hemolytic and Cytotoxic Activity of Procyanidin-Rich Extract from the Leaves of Actinidia arguta |
| title_short | In Vitro Studies of Anti-Hemolytic and Cytotoxic Activity of Procyanidin-Rich Extract from the Leaves of Actinidia arguta |
| title_sort | in vitro studies of anti hemolytic and cytotoxic activity of procyanidin rich extract from the leaves of actinidia arguta |
| topic | anti-hemolytic activity cytotoxic activity L5178Y cells multidrug resistance mini-kiwi (Actinidia arguta) |
| url | http://www.degruyter.com/view/j/pjfns.2018.68.issue-2/pjfns-2017-0021/pjfns-2017-0021.xml?format=INT |
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