Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters
Periodontitis is a chronic inflammatory condition that may contribute to diabetogenesis. The aim was to investigate the levels of glycated proteins and their correlation with periodontal and systemic inflammation. Fifty-one patients with periodontitis and 20 healthy subjects underwent probing pocket...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/6450742 |
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| author | Jeneen Panezai Mohammad Altamash Per-Erik Engstrӧm Anders Larsson |
| author_facet | Jeneen Panezai Mohammad Altamash Per-Erik Engstrӧm Anders Larsson |
| author_sort | Jeneen Panezai |
| collection | DOAJ |
| description | Periodontitis is a chronic inflammatory condition that may contribute to diabetogenesis. The aim was to investigate the levels of glycated proteins and their correlation with periodontal and systemic inflammation. Fifty-one patients with periodontitis and 20 healthy subjects underwent probing pocket depth (PPD) measurements. PPD total and PPD disease with and without tooth adjustment were used as continuous indices. Marginal bone loss (MBL) for mandibular premolars and molars was measured digitally. Body mass index (BMI) and waist circumference (WC) were also analyzed. Glycated hemoglobin (HbA1c) and fructosamine (FrAm) levels were measured in all subjects. A multiplex proximity extension assay (PEA) was used to analyze the serum samples for simultaneous measurement of 92 proteins. Both HbA1c and FrAm inversely correlated with IL-10, FGF-21, MCP-1, and TNF beta amongst 16 proteins. HbA1c correlated directly with OPG. Parameters of disease severity were consistently significant for HbA1c. Adjusted PPD total and number of missing teeth were increased in diabetes whereas levels of RANKL and RANKL to OPG ratio were the highest in nondiabetic periodontitis patients. Hyperglycemic conditions in periodontitis patients are associated with reduced levels of anti-inflammatory proteins as well as dysregulated bone resorption. |
| format | Article |
| id | doaj-art-b9e1e183fa164c1da98db18c58747ed3 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-b9e1e183fa164c1da98db18c58747ed32025-02-03T06:08:07ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/64507426450742Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease ParametersJeneen Panezai0Mohammad Altamash1Per-Erik Engstrӧm2Anders Larsson3Altamash Institute of Dental Medicine, Department of Periodontology, Karachi, PakistanAltamash Institute of Dental Medicine, Department of Periodontology, Karachi, PakistanKarolinska Institutet, Department of Dental Medicine, Division of Oral Diseases, Section of Periodontology, Huddinge, SwedenUppsala University, Department of Medical Sciences, Uppsala, SwedenPeriodontitis is a chronic inflammatory condition that may contribute to diabetogenesis. The aim was to investigate the levels of glycated proteins and their correlation with periodontal and systemic inflammation. Fifty-one patients with periodontitis and 20 healthy subjects underwent probing pocket depth (PPD) measurements. PPD total and PPD disease with and without tooth adjustment were used as continuous indices. Marginal bone loss (MBL) for mandibular premolars and molars was measured digitally. Body mass index (BMI) and waist circumference (WC) were also analyzed. Glycated hemoglobin (HbA1c) and fructosamine (FrAm) levels were measured in all subjects. A multiplex proximity extension assay (PEA) was used to analyze the serum samples for simultaneous measurement of 92 proteins. Both HbA1c and FrAm inversely correlated with IL-10, FGF-21, MCP-1, and TNF beta amongst 16 proteins. HbA1c correlated directly with OPG. Parameters of disease severity were consistently significant for HbA1c. Adjusted PPD total and number of missing teeth were increased in diabetes whereas levels of RANKL and RANKL to OPG ratio were the highest in nondiabetic periodontitis patients. Hyperglycemic conditions in periodontitis patients are associated with reduced levels of anti-inflammatory proteins as well as dysregulated bone resorption.http://dx.doi.org/10.1155/2020/6450742 |
| spellingShingle | Jeneen Panezai Mohammad Altamash Per-Erik Engstrӧm Anders Larsson Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters Journal of Diabetes Research |
| title | Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters |
| title_full | Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters |
| title_fullStr | Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters |
| title_full_unstemmed | Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters |
| title_short | Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters |
| title_sort | association of glycated proteins with inflammatory proteins and periodontal disease parameters |
| url | http://dx.doi.org/10.1155/2020/6450742 |
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