The Mechanical Components of the Dynein Motor
Unlike our understanding of the other two classes of cytoskeletal motor proteins, the myosins and kinesins, we have only recently begun to comprehend the molecular mechanism for how dynein produces force and movement. The slow progress has been attributed, in part, to the enormous size of the dynein...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.76 |
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| _version_ | 1832547460299358208 |
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| author | Peter Höök |
| author_facet | Peter Höök |
| author_sort | Peter Höök |
| collection | DOAJ |
| description | Unlike our understanding of the other two classes of cytoskeletal motor proteins, the myosins and kinesins, we have only recently begun to comprehend the molecular mechanism for how dynein produces force and movement. The slow progress has been attributed, in part, to the enormous size of the dynein force-producing head, but also to the complex interplay between its structural components, each of which has a unique role in regulating dynein motor activity. The integrated and highly coordinated mechanism by which these structures work together in powering the dynein machinery is discussed in this review. |
| format | Article |
| id | doaj-art-b9dd3a99374a441c90327148d574e35d |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-b9dd3a99374a441c90327148d574e35d2025-02-03T06:44:37ZengWileyThe Scientific World Journal1537-744X2010-01-011085786410.1100/tsw.2010.76The Mechanical Components of the Dynein MotorPeter Höök0Department of Pathology and Cell Biology, Columbia University, New York, NY, USAUnlike our understanding of the other two classes of cytoskeletal motor proteins, the myosins and kinesins, we have only recently begun to comprehend the molecular mechanism for how dynein produces force and movement. The slow progress has been attributed, in part, to the enormous size of the dynein force-producing head, but also to the complex interplay between its structural components, each of which has a unique role in regulating dynein motor activity. The integrated and highly coordinated mechanism by which these structures work together in powering the dynein machinery is discussed in this review.http://dx.doi.org/10.1100/tsw.2010.76 |
| spellingShingle | Peter Höök The Mechanical Components of the Dynein Motor The Scientific World Journal |
| title | The Mechanical Components of the Dynein Motor |
| title_full | The Mechanical Components of the Dynein Motor |
| title_fullStr | The Mechanical Components of the Dynein Motor |
| title_full_unstemmed | The Mechanical Components of the Dynein Motor |
| title_short | The Mechanical Components of the Dynein Motor |
| title_sort | mechanical components of the dynein motor |
| url | http://dx.doi.org/10.1100/tsw.2010.76 |
| work_keys_str_mv | AT peterhook themechanicalcomponentsofthedyneinmotor AT peterhook mechanicalcomponentsofthedyneinmotor |