Muscle parameters in men and oxidative stress markers
Abstract Background The oxidative handicap hypothesis posits that testosterone-dependent traits, such as muscle mass and strength, may be costly to develop due to testosterone’s pro-oxidative properties, leading to increased oxidative stress. This hypothesis suggests that only individuals with super...
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2025-01-01
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| Series: | Journal of Physiological Anthropology |
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| Online Access: | https://doi.org/10.1186/s40101-025-00385-8 |
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| author | Michał Pietruszewski Judyta Nowak-Kornicka Agnieszka Żelaźniewicz Bogusław Pawłowski |
| author_facet | Michał Pietruszewski Judyta Nowak-Kornicka Agnieszka Żelaźniewicz Bogusław Pawłowski |
| author_sort | Michał Pietruszewski |
| collection | DOAJ |
| description | Abstract Background The oxidative handicap hypothesis posits that testosterone-dependent traits, such as muscle mass and strength, may be costly to develop due to testosterone’s pro-oxidative properties, leading to increased oxidative stress. This hypothesis suggests that only individuals with superior biological conditions can afford these costs. This study examines the oxidative handicap hypothesis, exploring the relationship between muscle mass or handgrip strength and oxidative stress markers in men. Methods Handgrip strength and muscle mass were measured in 179 men, with muscle mass assessed using bioelectrical impedance analysis (BIA) and handgrip strength measured using a hydraulic dynamometer. Serum testosterone levels and antioxidant capacity were measured. 8-OH-dG, 8-epi-PGF2α, and protein carbonyls were measured to evaluate oxidative stress level. Pearson’s correlation and multivariate regression analyses were performed to examine the relationships between handgrip strength, muscle mass, and oxidative stress markers, controlling for age, serum testosterone levels, and antioxidant capacity. Results No significant correlations were found between handgrip strength and oxidative stress markers, even when controlling for muscle mass, antioxidant capacity, testosterone levels, and age. Conclusions The study’s findings do not support the oxidative handicap hypothesis in the context of muscle parameters in men. The results suggest that testosterone-driven traits like handgrip strength or muscle mass may not necessarily incur oxidative stress costs in healthy young men, possibly due to effective compensatory antioxidant mechanisms. Factors like lifestyle, diet, and genetic predisposition, which were not controlled in this study, could also influence the observed outcomes and should be included in future research. |
| format | Article |
| id | doaj-art-b9c9978dfa6a451f97bfb5ef674bd991 |
| institution | Kabale University |
| issn | 1880-6805 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Physiological Anthropology |
| spelling | doaj-art-b9c9978dfa6a451f97bfb5ef674bd9912025-01-19T12:42:53ZengBMCJournal of Physiological Anthropology1880-68052025-01-014411810.1186/s40101-025-00385-8Muscle parameters in men and oxidative stress markersMichał Pietruszewski0Judyta Nowak-Kornicka1Agnieszka Żelaźniewicz2Bogusław Pawłowski3University of WrocławUniversity of WrocławUniversity of WrocławUniversity of WrocławAbstract Background The oxidative handicap hypothesis posits that testosterone-dependent traits, such as muscle mass and strength, may be costly to develop due to testosterone’s pro-oxidative properties, leading to increased oxidative stress. This hypothesis suggests that only individuals with superior biological conditions can afford these costs. This study examines the oxidative handicap hypothesis, exploring the relationship between muscle mass or handgrip strength and oxidative stress markers in men. Methods Handgrip strength and muscle mass were measured in 179 men, with muscle mass assessed using bioelectrical impedance analysis (BIA) and handgrip strength measured using a hydraulic dynamometer. Serum testosterone levels and antioxidant capacity were measured. 8-OH-dG, 8-epi-PGF2α, and protein carbonyls were measured to evaluate oxidative stress level. Pearson’s correlation and multivariate regression analyses were performed to examine the relationships between handgrip strength, muscle mass, and oxidative stress markers, controlling for age, serum testosterone levels, and antioxidant capacity. Results No significant correlations were found between handgrip strength and oxidative stress markers, even when controlling for muscle mass, antioxidant capacity, testosterone levels, and age. Conclusions The study’s findings do not support the oxidative handicap hypothesis in the context of muscle parameters in men. The results suggest that testosterone-driven traits like handgrip strength or muscle mass may not necessarily incur oxidative stress costs in healthy young men, possibly due to effective compensatory antioxidant mechanisms. Factors like lifestyle, diet, and genetic predisposition, which were not controlled in this study, could also influence the observed outcomes and should be included in future research.https://doi.org/10.1186/s40101-025-00385-8Oxidative stressTestosteroneMuscle strengthHandgrip strength (HGS)Oxidative handicapHypothesis |
| spellingShingle | Michał Pietruszewski Judyta Nowak-Kornicka Agnieszka Żelaźniewicz Bogusław Pawłowski Muscle parameters in men and oxidative stress markers Journal of Physiological Anthropology Oxidative stress Testosterone Muscle strength Handgrip strength (HGS) Oxidative handicap Hypothesis |
| title | Muscle parameters in men and oxidative stress markers |
| title_full | Muscle parameters in men and oxidative stress markers |
| title_fullStr | Muscle parameters in men and oxidative stress markers |
| title_full_unstemmed | Muscle parameters in men and oxidative stress markers |
| title_short | Muscle parameters in men and oxidative stress markers |
| title_sort | muscle parameters in men and oxidative stress markers |
| topic | Oxidative stress Testosterone Muscle strength Handgrip strength (HGS) Oxidative handicap Hypothesis |
| url | https://doi.org/10.1186/s40101-025-00385-8 |
| work_keys_str_mv | AT michałpietruszewski muscleparametersinmenandoxidativestressmarkers AT judytanowakkornicka muscleparametersinmenandoxidativestressmarkers AT agnieszkazelazniewicz muscleparametersinmenandoxidativestressmarkers AT bogusławpawłowski muscleparametersinmenandoxidativestressmarkers |