Estimating progression of Alzheimer’s disease with extracellular vesicle-related multi-omics risk models

Estimating progression of Alzheimer’s disease with extracellular vesicle-related multi-omics risk models

BackgroundAlzheimer’s Disease (AD) is heterogeneous and shows complex interconnected pathways at various biological levels. Risk scores contribute greatly to disease prognosis and biomarker discovery but typically represent generic risk factors. However, large-scale multi-omics data can generate ind...

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Bibliographic Details
Main Authors: Xiao Zhang, Sanoji Wijenayake, Shakhawat Hossain, Qian Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
multiomics
extracellular vesicles (EV)
LASSO
Cox regression
biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1617611/full
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