Development and validation of a basement membrane inflammatory response gene signature in lung adenocarcinoma

Development and validation of a basement membrane inflammatory response gene signature in lung adenocarcinoma

Abstract Inflammatory cell infiltration within the tumor microenvironment compromises the basement membrane’ integrity, contributing to chemotherapy resistance and distant metastasis. This study investigates the interplay between inflammatory responses and basement membrane-related genes (BMIRGs) in...

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Bibliographic Details
Main Authors: Shilei Liu, Fengchu Liao, Qingming Xie, Sai Zhang, Dehong Tan, Xuesheng Xu, Jianlan Luo, Xujun Liang, Pengfei Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Lung adenocarcinoma
Basement membrane
Inflammatory response
Prognosis
Immune microenvironment
Online Access:https://doi.org/10.1038/s41598-025-05582-0
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