Drug-induced differential culturability in diverse strains of Mycobacterium tuberculosis

Drug-induced differential culturability in diverse strains of Mycobacterium tuberculosis

Abstract Under stress, bacteria display selective growth propensities on solid and liquid media. For Mycobacterium tuberculosis (Mtb), differentially culturable bacteria have been found in tuberculosis (TB) patient sputa. We hypothesized that antibiotic treatment can induce selective culturability i...

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Main Authors: Valerie F. A. March, Nino Maghradze, Kakha Mchedlishvili, Teona Avaliani, Rusudan Aspindzelashvili, Zaza Avaliani, Maia Kipiani, Nestani Tukvadze, Levan Jugheli, Selim Bouaouina, Anna Doetsch, Galo A. Goig, Sebastien Gagneux, Sonia Borrell
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Mycobacterium tuberculosis
Culturability
Viable but non culturable (VBNC)
Antibiotics
Isoniazid
Rifampicin
Online Access:https://doi.org/10.1038/s41598-024-85092-7
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https://doi.org/10.1038/s41598-024-85092-7

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