Multiomic analysis of human kidney disease identifies a tractable inflammatory and pro-fibrotic tubular cell phenotype

Multiomic analysis of human kidney disease identifies a tractable inflammatory and pro-fibrotic tubular cell phenotype

Abstract Maladaptive proximal tubular (PT) epithelial cells have been implicated in progression of chronic kidney disease (CKD), however the complexity of epithelial cell states within the fibrotic niche remains incompletely understood. Hence, we integrated snRNA and ATAC-seq with high-plex single-c...

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Main Authors: Maximilian Reck, David P. Baird, Stefan Veizades, Callum Sutherland, Rachel M. B. Bell, Heeyoun Hur, Carolynn Cairns, Piotr P. Janas, Ross Campbell, Andy Nam, Wei Yang, Nathan Schurman, Claire Williams, Eoin O’Sullivan, Meryam Beniazza, Andrea Corsinotti, Christopher Bellamy, Jeremy Hughes, Alexander Laird, Laura Denby, Tamir Chandra, David A. Ferenbach, Bryan R. Conway
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59997-4
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