Fertility induction associated with improved peripheral reproductive parameters in male Prop1df/dfmice subjected to GH and levothyroxine replacement
ABSTRACT Objective: The aim of this study was to characterize the parameters of reproductive anatomy and pituitary hormone expression levels in ames dwarf mice (Prop1df/df). Materials and methods: Male Prop1df/df mice aged 30 days received daily intraperitoneal injections of recombinant human GH a...
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Brazilian Society of Endocrinology and Metabolism
2025-01-01
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| Series: | Archives of Endocrinology and Metabolism |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000303&lng=en&tlng=en |
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| author | Bruna Viscardi Azevedo Juliana Moreira Marques Nicholas Trigueiro Victor Yuji Yariwake Mariana Matera Veras Leticia Kaory Tamashiro Robison Cruz Luciani R. Silveira de Carvalho |
| author_facet | Bruna Viscardi Azevedo Juliana Moreira Marques Nicholas Trigueiro Victor Yuji Yariwake Mariana Matera Veras Leticia Kaory Tamashiro Robison Cruz Luciani R. Silveira de Carvalho |
| author_sort | Bruna Viscardi Azevedo |
| collection | DOAJ |
| description | ABSTRACT Objective: The aim of this study was to characterize the parameters of reproductive anatomy and pituitary hormone expression levels in ames dwarf mice (Prop1df/df). Materials and methods: Male Prop1df/df mice aged 30 days received daily intraperitoneal injections of recombinant human GH and levothyroxine three times weekly for 60 days. The sexual maturation of these animals was compared with that of their wild-type (Prop+/+) and untreated (Prop1df/df) siblings. Results: The Prop1df/df treated group developed sexual maturation 2 weeks later than the Prop+/+ group and presented an increase in testicular weight, complete spermatogenesis, and enhanced LH and FSH expression. The Prop1df/df untreated group had low FSH expression and no offspring; most animals in this group did not develop sexual maturation during the study period. Conclusion: Replacement with GH and levothyroxine appeared to play a crucial role in restoring peripheral reproductive parameters and increasing pituitary hormone expression in Prop1df/df mice. |
| format | Article |
| id | doaj-art-b9919359448d48999147bafb028f0a10 |
| institution | Kabale University |
| issn | 2359-4292 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj-art-b9919359448d48999147bafb028f0a102025-01-21T07:45:09ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922025-01-0168spe110.20945/2359-4292-2024-0086Fertility induction associated with improved peripheral reproductive parameters in male Prop1df/dfmice subjected to GH and levothyroxine replacementBruna Viscardi Azevedohttps://orcid.org/0000-0002-7296-2378Juliana Moreira Marqueshttps://orcid.org/0000-0001-8760-1957Nicholas Trigueirohttps://orcid.org/0000-0003-1068-3231Victor Yuji Yariwakehttps://orcid.org/0000-0003-0639-1228Mariana Matera Verashttps://orcid.org/0000-0002-8363-4329Leticia Kaory Tamashirohttps://orcid.org/0000-0001-8631-0613Robison Cruzhttps://orcid.org/0009-0008-8985-5844Luciani R. Silveira de Carvalhohttps://orcid.org/0000-0002-7313-2130ABSTRACT Objective: The aim of this study was to characterize the parameters of reproductive anatomy and pituitary hormone expression levels in ames dwarf mice (Prop1df/df). Materials and methods: Male Prop1df/df mice aged 30 days received daily intraperitoneal injections of recombinant human GH and levothyroxine three times weekly for 60 days. The sexual maturation of these animals was compared with that of their wild-type (Prop+/+) and untreated (Prop1df/df) siblings. Results: The Prop1df/df treated group developed sexual maturation 2 weeks later than the Prop+/+ group and presented an increase in testicular weight, complete spermatogenesis, and enhanced LH and FSH expression. The Prop1df/df untreated group had low FSH expression and no offspring; most animals in this group did not develop sexual maturation during the study period. Conclusion: Replacement with GH and levothyroxine appeared to play a crucial role in restoring peripheral reproductive parameters and increasing pituitary hormone expression in Prop1df/df mice.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000303&lng=en&tlng=enAmes dwarf micecongenital hypopituitarismpubertysexual maturationpituitary |
| spellingShingle | Bruna Viscardi Azevedo Juliana Moreira Marques Nicholas Trigueiro Victor Yuji Yariwake Mariana Matera Veras Leticia Kaory Tamashiro Robison Cruz Luciani R. Silveira de Carvalho Fertility induction associated with improved peripheral reproductive parameters in male Prop1df/dfmice subjected to GH and levothyroxine replacement Archives of Endocrinology and Metabolism Ames dwarf mice congenital hypopituitarism puberty sexual maturation pituitary |
| title | Fertility induction associated with improved peripheral reproductive parameters in male Prop1df/dfmice subjected to GH and levothyroxine replacement |
| title_full | Fertility induction associated with improved peripheral reproductive parameters in male Prop1df/dfmice subjected to GH and levothyroxine replacement |
| title_fullStr | Fertility induction associated with improved peripheral reproductive parameters in male Prop1df/dfmice subjected to GH and levothyroxine replacement |
| title_full_unstemmed | Fertility induction associated with improved peripheral reproductive parameters in male Prop1df/dfmice subjected to GH and levothyroxine replacement |
| title_short | Fertility induction associated with improved peripheral reproductive parameters in male Prop1df/dfmice subjected to GH and levothyroxine replacement |
| title_sort | fertility induction associated with improved peripheral reproductive parameters in male prop1df dfmice subjected to gh and levothyroxine replacement |
| topic | Ames dwarf mice congenital hypopituitarism puberty sexual maturation pituitary |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000303&lng=en&tlng=en |
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