Mutation of lysine-specific demethylase 5 is associated with enhanced tumor immunity and favorable outcomes in pan-cancer immune checkpoint blockade

Mutation of lysine-specific demethylase 5 is associated with enhanced tumor immunity and favorable outcomes in pan-cancer immune checkpoint blockade

Abstract The lysine-specific demethylase 5 (KDM5) family, a key post-translational modification of chromatin, can shape tumor immune microenvironment. Here, we performed an extensive clinical and bioinformatic analysis to explore the association between KDM5 mutation and tumor immunity and its impac...

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Bibliographic Details
Main Authors: Xiaofeng Li, Zhishan Zhang, Yingying Li, Lijin Chen, Yan Huang, Lijuan Su, Wenjun Xu, Yanni Hong, Jianjiao Li, Mujin Chen, Hongkui Yang, Hong Zhao, Bin Zhao
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Cancer
Subjects:
KDM5
Cancer immunotherapy
Biomarker
Tumor immunity
Online Access:https://doi.org/10.1186/s12943-024-02197-3
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