Virus-Mimicking Polymer Nanocomplexes Co-Assembling HCV E1E2 and Core Proteins with TLR 7/8 Agonist—Synthesis, Characterization, and In Vivo Activity

Virus-Mimicking Polymer Nanocomplexes Co-Assembling HCV E1E2 and Core Proteins with TLR 7/8 Agonist—Synthesis, Characterization, and In Vivo Activity

Hepatitis C virus (HCV) is a major public health concern, and the development of an effective HCV vaccine plays an important role in the effort to prevent new infections. Supramolecular co-assembly and co-presentation of the HCV envelope E1E2 heterodimer complex and core protein presents an attracti...

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Bibliographic Details
Main Authors: Thomas R. Fuerst, Alexander Marin, Sarah Jeong, Liudmila Kulakova, Raman Hlushko, Katrina Gorga, Eric A. Toth, Nevil J. Singh, Alexander K. Andrianov
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Journal of Functional Biomaterials
Subjects:
polyphosphazenes
polymer nanocomplexes
vaccine delivery
hepatitis C virus
immunoadjuvants
supramolecular assembly
Online Access:https://www.mdpi.com/2079-4983/16/1/34
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