Diverse Roles of Macrophages in Atherosclerosis: From Inflammatory Biology to Biomarker Discovery
Cardiovascular disease, a leading cause of mortality in developed countries, is mainly caused by atherosclerosis, a chronic inflammatory disease. Macrophages, which differentiate from monocytes that are recruited from the blood, account for the majority of leukocytes in atherosclerotic plaques. Apop...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/693083 |
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| _version_ | 1832565125808128000 |
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| author | Ting Gui Aiko Shimokado Yujing Sun Takashi Akasaka Yasuteru Muragaki |
| author_facet | Ting Gui Aiko Shimokado Yujing Sun Takashi Akasaka Yasuteru Muragaki |
| author_sort | Ting Gui |
| collection | DOAJ |
| description | Cardiovascular disease, a leading cause of mortality in developed countries, is mainly caused by atherosclerosis, a chronic inflammatory disease. Macrophages, which differentiate from monocytes that are recruited from the blood, account for the majority of leukocytes in atherosclerotic plaques. Apoptosis and the suppressed clearance of apoptotic macrophages (efferocytosis) are associated with vulnerable plaques that are prone to rupture, leading to thrombosis. Based on the central functions of macrophages in atherogenesis, cytokines, chemokines, enzymes, or microRNAs related to or produced by macrophages have become important clinical prognostic or diagnostic biomarkers. This paper discusses the impact of monocyte-derived macrophages in early atherogenesis and advanced disease. The role and possible future development of macrophage inflammatory biomarkers are also described. |
| format | Article |
| id | doaj-art-b96957ce740f473583e670faf946e75b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b96957ce740f473583e670faf946e75b2025-02-03T01:09:12ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/693083693083Diverse Roles of Macrophages in Atherosclerosis: From Inflammatory Biology to Biomarker DiscoveryTing Gui0Aiko Shimokado1Yujing Sun2Takashi Akasaka3Yasuteru Muragaki4First Department of Pathology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, JapanFirst Department of Pathology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, JapanFirst Department of Pathology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, JapanDepartment of Cardiovascular Medicine, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, JapanFirst Department of Pathology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, JapanCardiovascular disease, a leading cause of mortality in developed countries, is mainly caused by atherosclerosis, a chronic inflammatory disease. Macrophages, which differentiate from monocytes that are recruited from the blood, account for the majority of leukocytes in atherosclerotic plaques. Apoptosis and the suppressed clearance of apoptotic macrophages (efferocytosis) are associated with vulnerable plaques that are prone to rupture, leading to thrombosis. Based on the central functions of macrophages in atherogenesis, cytokines, chemokines, enzymes, or microRNAs related to or produced by macrophages have become important clinical prognostic or diagnostic biomarkers. This paper discusses the impact of monocyte-derived macrophages in early atherogenesis and advanced disease. The role and possible future development of macrophage inflammatory biomarkers are also described.http://dx.doi.org/10.1155/2012/693083 |
| spellingShingle | Ting Gui Aiko Shimokado Yujing Sun Takashi Akasaka Yasuteru Muragaki Diverse Roles of Macrophages in Atherosclerosis: From Inflammatory Biology to Biomarker Discovery Mediators of Inflammation |
| title | Diverse Roles of Macrophages in Atherosclerosis: From Inflammatory Biology to Biomarker Discovery |
| title_full | Diverse Roles of Macrophages in Atherosclerosis: From Inflammatory Biology to Biomarker Discovery |
| title_fullStr | Diverse Roles of Macrophages in Atherosclerosis: From Inflammatory Biology to Biomarker Discovery |
| title_full_unstemmed | Diverse Roles of Macrophages in Atherosclerosis: From Inflammatory Biology to Biomarker Discovery |
| title_short | Diverse Roles of Macrophages in Atherosclerosis: From Inflammatory Biology to Biomarker Discovery |
| title_sort | diverse roles of macrophages in atherosclerosis from inflammatory biology to biomarker discovery |
| url | http://dx.doi.org/10.1155/2012/693083 |
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