Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations.
Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft-versus-host...
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| Language: | English |
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Public Library of Science (PLoS)
2007-06-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030103&type=printable |
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| author | Eric Spierings Matthijs Hendriks Léna Absi Angelica Canossi Sonal Chhaya John Crowley Harry Dolstra Jean-François Eliaou Tom Ellis Jürgen Enczmann Maria E Fasano Thibaut Gervais Clara Gorodezky Brigitte Kircher David Laurin Mary S Leffell Pascale Loiseau Mari Malkki Miroslaw Markiewicz Miryam Martinetti Etsuko Maruya Narinder Mehra Fatma Oguz Machteld Oudshoorn Noemi Pereira Rajni Rani Ruhena Sergeant Jackie Thomson Thuong Hien Tran Hannu Turpeinen Kuo-Liang Yang Renata Zunec Mary Carrington Peter de Knijff Els Goulmy |
| author_facet | Eric Spierings Matthijs Hendriks Léna Absi Angelica Canossi Sonal Chhaya John Crowley Harry Dolstra Jean-François Eliaou Tom Ellis Jürgen Enczmann Maria E Fasano Thibaut Gervais Clara Gorodezky Brigitte Kircher David Laurin Mary S Leffell Pascale Loiseau Mari Malkki Miroslaw Markiewicz Miryam Martinetti Etsuko Maruya Narinder Mehra Fatma Oguz Machteld Oudshoorn Noemi Pereira Rajni Rani Ruhena Sergeant Jackie Thomson Thuong Hien Tran Hannu Turpeinen Kuo-Liang Yang Renata Zunec Mary Carrington Peter de Knijff Els Goulmy |
| author_sort | Eric Spierings |
| collection | DOAJ |
| description | Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft-versus-host disease, and in the curative graft-versus-tumor effect of SCT. The latter characteristic enabled the current application of selected minor H antigens in clinical immunotherapeutic SCT protocols. No information exists on the global phenotypic distribution of the currently identified minor H antigens. Therefore, an estimation of their overall impact in human leukocyte antigen-matched solid organ and SCT in the major ethnic populations is still lacking. For the first time, a worldwide phenotype frequency analysis of ten autosomal minor H antigens was executed by 31 laboratories and comprised 2,685 randomly selected individuals from six major ethnic populations. Significant differences in minor H antigen frequencies were observed between the ethnic populations, some of which appeared to be geographically correlated. |
| format | Article |
| id | doaj-art-b95e2c17c8d74b7e8a44a4306cbe19db |
| institution | OA Journals |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2007-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-b95e2c17c8d74b7e8a44a4306cbe19db2025-08-20T02:00:55ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042007-06-0136e10310.1371/journal.pgen.0030103Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations.Eric SpieringsMatthijs HendriksLéna AbsiAngelica CanossiSonal ChhayaJohn CrowleyHarry DolstraJean-François EliaouTom EllisJürgen EnczmannMaria E FasanoThibaut GervaisClara GorodezkyBrigitte KircherDavid LaurinMary S LeffellPascale LoiseauMari MalkkiMiroslaw MarkiewiczMiryam MartinettiEtsuko MaruyaNarinder MehraFatma OguzMachteld OudshoornNoemi PereiraRajni RaniRuhena SergeantJackie ThomsonThuong Hien TranHannu TurpeinenKuo-Liang YangRenata ZunecMary CarringtonPeter de KnijffEls GoulmyMinor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched solid organ and stem cell transplantation (SCT). Minor H antigens are instrumental in the processes of transplant rejection, graft-versus-host disease, and in the curative graft-versus-tumor effect of SCT. The latter characteristic enabled the current application of selected minor H antigens in clinical immunotherapeutic SCT protocols. No information exists on the global phenotypic distribution of the currently identified minor H antigens. Therefore, an estimation of their overall impact in human leukocyte antigen-matched solid organ and SCT in the major ethnic populations is still lacking. For the first time, a worldwide phenotype frequency analysis of ten autosomal minor H antigens was executed by 31 laboratories and comprised 2,685 randomly selected individuals from six major ethnic populations. Significant differences in minor H antigen frequencies were observed between the ethnic populations, some of which appeared to be geographically correlated.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030103&type=printable |
| spellingShingle | Eric Spierings Matthijs Hendriks Léna Absi Angelica Canossi Sonal Chhaya John Crowley Harry Dolstra Jean-François Eliaou Tom Ellis Jürgen Enczmann Maria E Fasano Thibaut Gervais Clara Gorodezky Brigitte Kircher David Laurin Mary S Leffell Pascale Loiseau Mari Malkki Miroslaw Markiewicz Miryam Martinetti Etsuko Maruya Narinder Mehra Fatma Oguz Machteld Oudshoorn Noemi Pereira Rajni Rani Ruhena Sergeant Jackie Thomson Thuong Hien Tran Hannu Turpeinen Kuo-Liang Yang Renata Zunec Mary Carrington Peter de Knijff Els Goulmy Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations. PLoS Genetics |
| title | Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations. |
| title_full | Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations. |
| title_fullStr | Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations. |
| title_full_unstemmed | Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations. |
| title_short | Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations. |
| title_sort | phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030103&type=printable |
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