Cytokine production of mononuclear leukocytes in response to respiratory syncytial virus is increased in COPD but suppressed in non-COPD tobacco smokers

Cytokine production of mononuclear leukocytes in response to respiratory syncytial virus is increased in COPD but suppressed in non-COPD tobacco smokers

Abstract Background Respiratory syncytial virus (RSV) induces exacerbations of chronic obstructive pulmonary disease (COPD) that are critical for disease progression and burden. COPD subjects have an increased susceptibility to viral respiratory infections. We aimed to identify underlying systemic i...

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Main Authors: Sarah D. Yanik, Kaschin Jamal Jameel, Simon Rohde, Paul Bürger, Eike Bülthoff, Thomas Grunwald, Juliane Kronsbein, Andrea Koch, Michael R. Edwards, Matthias Tenbusch, Jürgen Knobloch
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Medicine
Subjects:
RSV
COPD
Exacerbation
Circulating immune cells
Cytokine overproduction
Online Access:https://doi.org/10.1186/s10020-025-01277-4
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