Metabolomics-Driven Insights into Biomarkers for Poor Ovarian Response: A Narrative Review
Poor ovarian response (POR) remains a significant challenge in the field of assisted reproductive technology (ART), as the quantity and quality of oocytes retrieved directly influence embryo implantation, clinical pregnancy, and live birth rates. Metabolomics has become a valuable tool for elucidati...
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2025-01-01
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| author | Anastasios Potiris Sofoklis Stavros Eleni Alyfanti Nikolaos Machairiotis Eirini Drakaki Athanasios Zikopoulos Efthalia Moustakli Charikleia Skentou Peter Drakakis Ekaterini Domali |
| author_facet | Anastasios Potiris Sofoklis Stavros Eleni Alyfanti Nikolaos Machairiotis Eirini Drakaki Athanasios Zikopoulos Efthalia Moustakli Charikleia Skentou Peter Drakakis Ekaterini Domali |
| author_sort | Anastasios Potiris |
| collection | DOAJ |
| description | Poor ovarian response (POR) remains a significant challenge in the field of assisted reproductive technology (ART), as the quantity and quality of oocytes retrieved directly influence embryo implantation, clinical pregnancy, and live birth rates. Metabolomics has become a valuable tool for elucidating the molecular mechanisms underlying diminished ovarian reserve (DOR) and POR. This review aims to synthesize findings from metabolomic studies examining metabolite expression patterns in serum and follicular fluid samples from women with POR. A literature search was performed using the Medline/PubMed and Scopus databases, employing keywords related to metabolomics and POR. In total, nine studies met the inclusion criteria for this review. These studies identified several metabolites with differential expression in serum and follicular fluid samples between women with normal ovarian response and those with POR. Although the metabolomic profiles varied significantly among studies, consistent alterations in prostaglandin related metabolites were observed in two of the nine studies reviewed. These findings suggest that, pending further validation, these metabolites may serve as potential biomarkers for ovarian response. Metabolomics has significantly advanced our understanding of the mechanisms underlying ovarian function and holds promise for identifying effective biomarkers that could improve the prediction and management of POR. |
| format | Article |
| id | doaj-art-b943f6e131c54e2891bf5fba3ccac3b2 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-b943f6e131c54e2891bf5fba3ccac3b22025-01-24T13:24:26ZengMDPI AGBiomedicines2227-90592025-01-0113121410.3390/biomedicines13010214Metabolomics-Driven Insights into Biomarkers for Poor Ovarian Response: A Narrative ReviewAnastasios Potiris0Sofoklis Stavros1Eleni Alyfanti2Nikolaos Machairiotis3Eirini Drakaki4Athanasios Zikopoulos5Efthalia Moustakli6Charikleia Skentou7Peter Drakakis8Ekaterini Domali9Third Department of Obstetrics and Gynecology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, GreeceThird Department of Obstetrics and Gynecology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, GreeceMedical School, National and Kapodistrian University of Athens, 115 27 Athens, GreeceThird Department of Obstetrics and Gynecology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, GreeceFirst Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, GreeceThird Department of Obstetrics and Gynecology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, GreeceLaboratory of Medical Genetics, Medical School, University of Ioannina, 451 10 Ioannina, GreeceDepartment of Obstetrics and Gynecology, Medical School, University of Ioannina, 451 10 Ioannina, GreeceThird Department of Obstetrics and Gynecology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, GreeceFirst Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, GreecePoor ovarian response (POR) remains a significant challenge in the field of assisted reproductive technology (ART), as the quantity and quality of oocytes retrieved directly influence embryo implantation, clinical pregnancy, and live birth rates. Metabolomics has become a valuable tool for elucidating the molecular mechanisms underlying diminished ovarian reserve (DOR) and POR. This review aims to synthesize findings from metabolomic studies examining metabolite expression patterns in serum and follicular fluid samples from women with POR. A literature search was performed using the Medline/PubMed and Scopus databases, employing keywords related to metabolomics and POR. In total, nine studies met the inclusion criteria for this review. These studies identified several metabolites with differential expression in serum and follicular fluid samples between women with normal ovarian response and those with POR. Although the metabolomic profiles varied significantly among studies, consistent alterations in prostaglandin related metabolites were observed in two of the nine studies reviewed. These findings suggest that, pending further validation, these metabolites may serve as potential biomarkers for ovarian response. Metabolomics has significantly advanced our understanding of the mechanisms underlying ovarian function and holds promise for identifying effective biomarkers that could improve the prediction and management of POR.https://www.mdpi.com/2227-9059/13/1/214poor ovarian response (POR)diminished ovarian reserve (DOR)metabolomicsfollicular fluid metabolomic profilesbiomarkers |
| spellingShingle | Anastasios Potiris Sofoklis Stavros Eleni Alyfanti Nikolaos Machairiotis Eirini Drakaki Athanasios Zikopoulos Efthalia Moustakli Charikleia Skentou Peter Drakakis Ekaterini Domali Metabolomics-Driven Insights into Biomarkers for Poor Ovarian Response: A Narrative Review Biomedicines poor ovarian response (POR) diminished ovarian reserve (DOR) metabolomics follicular fluid metabolomic profiles biomarkers |
| title | Metabolomics-Driven Insights into Biomarkers for Poor Ovarian Response: A Narrative Review |
| title_full | Metabolomics-Driven Insights into Biomarkers for Poor Ovarian Response: A Narrative Review |
| title_fullStr | Metabolomics-Driven Insights into Biomarkers for Poor Ovarian Response: A Narrative Review |
| title_full_unstemmed | Metabolomics-Driven Insights into Biomarkers for Poor Ovarian Response: A Narrative Review |
| title_short | Metabolomics-Driven Insights into Biomarkers for Poor Ovarian Response: A Narrative Review |
| title_sort | metabolomics driven insights into biomarkers for poor ovarian response a narrative review |
| topic | poor ovarian response (POR) diminished ovarian reserve (DOR) metabolomics follicular fluid metabolomic profiles biomarkers |
| url | https://www.mdpi.com/2227-9059/13/1/214 |
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