Thigmotropism of Malignant Melanoma Cells
During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. In particular, they progress along the dermoepidermal basement membrane, the hair follicles, the sweat gland apparatus, nerves, and the near perivascular...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/362784 |
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| author | Pascale Quatresooz Claudine Piérard-Franchimont Fanchon Noël Gérald E. Piérard |
| author_facet | Pascale Quatresooz Claudine Piérard-Franchimont Fanchon Noël Gérald E. Piérard |
| author_sort | Pascale Quatresooz |
| collection | DOAJ |
| description | During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. In particular, they progress along the dermoepidermal basement membrane, the hair follicles, the sweat gland apparatus, nerves, and the near perivascular space. These features evoke the thigmotropism phenomenon defined as a contact-sensing growth of cells. This process is likely connected to modulation in cell tensegrity (control of the cell shape). These specifically located paucicellular aggregates of MM cells do not appear to be involved in the tumorigenic growth phase, but rather they participate in the so-called “accretive” growth model. These MM cell collections are often part of the primary neoplasm, but they may, however, correspond to MM micrometastases and predict further local overt metastasis spread. |
| format | Article |
| id | doaj-art-b93829d861284018b94237150466e679 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-b93829d861284018b94237150466e6792025-02-03T07:24:39ZengWileyDermatology Research and Practice1687-61051687-61132012-01-01201210.1155/2012/362784362784Thigmotropism of Malignant Melanoma CellsPascale Quatresooz0Claudine Piérard-Franchimont1Fanchon Noël2Gérald E. Piérard3Department of Dermatopathology, University Hospital of Liège, 4000 Liège, BelgiumDepartment of Dermatopathology, University Hospital of Liège, 4000 Liège, BelgiumDepartment of Dermatopathology, University Hospital of Liège, 4000 Liège, BelgiumDepartment of Dermatopathology, University Hospital of Liège, 4000 Liège, BelgiumDuring malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. In particular, they progress along the dermoepidermal basement membrane, the hair follicles, the sweat gland apparatus, nerves, and the near perivascular space. These features evoke the thigmotropism phenomenon defined as a contact-sensing growth of cells. This process is likely connected to modulation in cell tensegrity (control of the cell shape). These specifically located paucicellular aggregates of MM cells do not appear to be involved in the tumorigenic growth phase, but rather they participate in the so-called “accretive” growth model. These MM cell collections are often part of the primary neoplasm, but they may, however, correspond to MM micrometastases and predict further local overt metastasis spread.http://dx.doi.org/10.1155/2012/362784 |
| spellingShingle | Pascale Quatresooz Claudine Piérard-Franchimont Fanchon Noël Gérald E. Piérard Thigmotropism of Malignant Melanoma Cells Dermatology Research and Practice |
| title | Thigmotropism of Malignant Melanoma Cells |
| title_full | Thigmotropism of Malignant Melanoma Cells |
| title_fullStr | Thigmotropism of Malignant Melanoma Cells |
| title_full_unstemmed | Thigmotropism of Malignant Melanoma Cells |
| title_short | Thigmotropism of Malignant Melanoma Cells |
| title_sort | thigmotropism of malignant melanoma cells |
| url | http://dx.doi.org/10.1155/2012/362784 |
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