Gut microbial metabolite butyrate suppresses hepatocellular carcinoma growth via CXCL11-dependent enhancement of natural killer cell infiltration

Gut microbial metabolite butyrate suppresses hepatocellular carcinoma growth via CXCL11-dependent enhancement of natural killer cell infiltration

Gut microbiota-derived butyrate plays a vital role in attenuating hepatocellular carcinoma (HCC) in murine models. However, the precise molecular mechanisms by which butyrate exerts its effects are largely undefined. Plasma short-chain fatty acids (SCFAs) were quantitatively measured by using gas ch...

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Bibliographic Details
Main Authors: Menghan Zhang, Xuefeng Huang, Yanlong Zhang, Minghang Yu, Xiaoxue Yuan, Yifan Xu, Lei Ma, Xi Wang, Huichun Xing
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Gut microbiota
butyrate
epigenetic
natural killer cells
hepatocellular carcinoma
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2519706
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