Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells
Natural killer T (NKT) cells constitute a unique subset of T lymphocytes characterized by specifically interacting with antigenic glycolipids conjugated to the CD1d receptor on antigen-presenting cells. Functionally, NKT cells are capable of performing either effector or suppressor immune responses,...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/5573937 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567681834811392 |
|---|---|
| author | Samanta Melgar-Rodríguez Emilio A. Cafferata Nicolás I. Díaz Miguel A. Peña Luis González-Osuna Carolina Rojas Alfredo Sierra-Cristancho Angélica M. Cárdenas Jaime Díaz-Zúñiga Rolando Vernal |
| author_facet | Samanta Melgar-Rodríguez Emilio A. Cafferata Nicolás I. Díaz Miguel A. Peña Luis González-Osuna Carolina Rojas Alfredo Sierra-Cristancho Angélica M. Cárdenas Jaime Díaz-Zúñiga Rolando Vernal |
| author_sort | Samanta Melgar-Rodríguez |
| collection | DOAJ |
| description | Natural killer T (NKT) cells constitute a unique subset of T lymphocytes characterized by specifically interacting with antigenic glycolipids conjugated to the CD1d receptor on antigen-presenting cells. Functionally, NKT cells are capable of performing either effector or suppressor immune responses, depending on their production of proinflammatory or anti-inflammatory cytokines, respectively. Effector NKT cells are subdivided into three subsets, termed NKT1, NKT2, and NKT17, based on the cytokines they produce and their similarity to the cytokine profile produced by Th1, Th2, and Th17 lymphocytes, respectively. Recently, a new subgroup of NKT cells termed NKT10 has been described, which cooperates and interacts with other immune cells to promote immunoregulatory responses. Although the tissue-specific functions of NKT cells have not been fully elucidated, their activity has been associated with the pathogenesis of different inflammatory diseases with immunopathogenic similarities to periodontitis, including osteolytic pathologies such as rheumatoid arthritis and osteoporosis. In the present review, we revise and discuss the pathogenic characteristics of NKT cells in these diseases and their role in the pathogenesis of periodontitis; particularly, we analyze the potential regulatory role of the IL-10-producing NKT10 cells. |
| format | Article |
| id | doaj-art-b9299b3bf73b428993ecbc2e13ff37c5 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b9299b3bf73b428993ecbc2e13ff37c52025-02-03T01:00:47ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/55739375573937Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 CellsSamanta Melgar-Rodríguez0Emilio A. Cafferata1Nicolás I. Díaz2Miguel A. Peña3Luis González-Osuna4Carolina Rojas5Alfredo Sierra-Cristancho6Angélica M. Cárdenas7Jaime Díaz-Zúñiga8Rolando Vernal9Periodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago, ChilePeriodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago, ChilePeriodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago, ChilePeriodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago, ChilePeriodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago, ChilePeriodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago, ChilePeriodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago, ChilePeriodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago, ChilePeriodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago, ChilePeriodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago, ChileNatural killer T (NKT) cells constitute a unique subset of T lymphocytes characterized by specifically interacting with antigenic glycolipids conjugated to the CD1d receptor on antigen-presenting cells. Functionally, NKT cells are capable of performing either effector or suppressor immune responses, depending on their production of proinflammatory or anti-inflammatory cytokines, respectively. Effector NKT cells are subdivided into three subsets, termed NKT1, NKT2, and NKT17, based on the cytokines they produce and their similarity to the cytokine profile produced by Th1, Th2, and Th17 lymphocytes, respectively. Recently, a new subgroup of NKT cells termed NKT10 has been described, which cooperates and interacts with other immune cells to promote immunoregulatory responses. Although the tissue-specific functions of NKT cells have not been fully elucidated, their activity has been associated with the pathogenesis of different inflammatory diseases with immunopathogenic similarities to periodontitis, including osteolytic pathologies such as rheumatoid arthritis and osteoporosis. In the present review, we revise and discuss the pathogenic characteristics of NKT cells in these diseases and their role in the pathogenesis of periodontitis; particularly, we analyze the potential regulatory role of the IL-10-producing NKT10 cells.http://dx.doi.org/10.1155/2021/5573937 |
| spellingShingle | Samanta Melgar-Rodríguez Emilio A. Cafferata Nicolás I. Díaz Miguel A. Peña Luis González-Osuna Carolina Rojas Alfredo Sierra-Cristancho Angélica M. Cárdenas Jaime Díaz-Zúñiga Rolando Vernal Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells Mediators of Inflammation |
| title | Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells |
| title_full | Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells |
| title_fullStr | Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells |
| title_full_unstemmed | Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells |
| title_short | Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells |
| title_sort | natural killer t nkt cells and periodontitis potential regulatory role of nkt10 cells |
| url | http://dx.doi.org/10.1155/2021/5573937 |
| work_keys_str_mv | AT samantamelgarrodriguez naturalkillertnktcellsandperiodontitispotentialregulatoryroleofnkt10cells AT emilioacafferata naturalkillertnktcellsandperiodontitispotentialregulatoryroleofnkt10cells AT nicolasidiaz naturalkillertnktcellsandperiodontitispotentialregulatoryroleofnkt10cells AT miguelapena naturalkillertnktcellsandperiodontitispotentialregulatoryroleofnkt10cells AT luisgonzalezosuna naturalkillertnktcellsandperiodontitispotentialregulatoryroleofnkt10cells AT carolinarojas naturalkillertnktcellsandperiodontitispotentialregulatoryroleofnkt10cells AT alfredosierracristancho naturalkillertnktcellsandperiodontitispotentialregulatoryroleofnkt10cells AT angelicamcardenas naturalkillertnktcellsandperiodontitispotentialregulatoryroleofnkt10cells AT jaimediazzuniga naturalkillertnktcellsandperiodontitispotentialregulatoryroleofnkt10cells AT rolandovernal naturalkillertnktcellsandperiodontitispotentialregulatoryroleofnkt10cells |