Impacts of COVID-19 on Pregnancy Outcomes: A Retrospective Study
Background: This study compared outcomes of pregnant females with and without COVID-19 and their fetuses/newborns. Methods: This is a retrospective study from 2020 to 2023 utilizing the United States Collaborative Network of the TriNetX Database. We compared the outcomes of pregnant females with COV...
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MDPI AG
2024-11-01
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| Series: | Emergency Care and Medicine |
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| author | Donna Mendez Krishna Paul Jerome L. Yaklic Dietrich Jehle |
| author_facet | Donna Mendez Krishna Paul Jerome L. Yaklic Dietrich Jehle |
| author_sort | Donna Mendez |
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| description | Background: This study compared outcomes of pregnant females with and without COVID-19 and their fetuses/newborns. Methods: This is a retrospective study from 2020 to 2023 utilizing the United States Collaborative Network of the TriNetX Database. We compared the outcomes of pregnant females with COVID-19 and pregnant females without COVID-19. Maternal outcomes evaluated were death, intubation, intensive care unit (ICU) admission, and premature rupture of membranes (PROM) within 9 months of the diagnosis of pregnancy. Fetal outcomes included preterm birth and intrauterine death (IUD). A subgroup analysis of outcomes was performed based on the mother’s vaccine status. Results: The risks of maternal death (RR = 1.97), maternal intubation (RR = 3.33), and maternal (ICU) admission (RR = 1.76) were significantly higher in pregnant females with COVID-19. For the neonate, there was a higher risk of preterm birth (RR = 1.12). When the confounders were eliminated with propensity matching, there was still an increase in maternal intubation (RR = 3.24) and maternal ICU admission (RR = 1.60). For the neonate/fetus, there was a decreased risk of PROM (RR = 0.83) and IUD (RR = 0.74) for the fetuses of the mothers with COVID-19. For the subgroup analysis, the mother was at an increased risk of ICU admission (RR = 0.04) when unvaccinated. Conclusions: There is an increased risk of poor outcomes for pregnant women infected with COVID-19; however, fetal outcomes are generally favorable. When unvaccinated, there was an increased risk of ICU admission for the mother. |
| format | Article |
| id | doaj-art-b900eb64e9bc43e0a90d6e50c34959ec |
| institution | Kabale University |
| issn | 2813-7914 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Emergency Care and Medicine |
| spelling | doaj-art-b900eb64e9bc43e0a90d6e50c34959ec2025-01-24T13:29:57ZengMDPI AGEmergency Care and Medicine2813-79142024-11-011443544210.3390/ecm1040043Impacts of COVID-19 on Pregnancy Outcomes: A Retrospective StudyDonna Mendez0Krishna Paul1Jerome L. Yaklic2Dietrich Jehle3Department of Emergency Medicine, University of Texas Medical Branch: Galveston, 301 University Blvd, Galveston, TX 77555-1173, USADepartment of Emergency Medicine, University of Texas Medical Branch: Galveston, 301 University Blvd, Galveston, TX 77555-1173, USADepartment of Emergency Medicine, University of Texas Medical Branch: Galveston, 301 University Blvd, Galveston, TX 77555-1173, USADepartment of Emergency Medicine, University of Texas Medical Branch: Galveston, 301 University Blvd, Galveston, TX 77555-1173, USABackground: This study compared outcomes of pregnant females with and without COVID-19 and their fetuses/newborns. Methods: This is a retrospective study from 2020 to 2023 utilizing the United States Collaborative Network of the TriNetX Database. We compared the outcomes of pregnant females with COVID-19 and pregnant females without COVID-19. Maternal outcomes evaluated were death, intubation, intensive care unit (ICU) admission, and premature rupture of membranes (PROM) within 9 months of the diagnosis of pregnancy. Fetal outcomes included preterm birth and intrauterine death (IUD). A subgroup analysis of outcomes was performed based on the mother’s vaccine status. Results: The risks of maternal death (RR = 1.97), maternal intubation (RR = 3.33), and maternal (ICU) admission (RR = 1.76) were significantly higher in pregnant females with COVID-19. For the neonate, there was a higher risk of preterm birth (RR = 1.12). When the confounders were eliminated with propensity matching, there was still an increase in maternal intubation (RR = 3.24) and maternal ICU admission (RR = 1.60). For the neonate/fetus, there was a decreased risk of PROM (RR = 0.83) and IUD (RR = 0.74) for the fetuses of the mothers with COVID-19. For the subgroup analysis, the mother was at an increased risk of ICU admission (RR = 0.04) when unvaccinated. Conclusions: There is an increased risk of poor outcomes for pregnant women infected with COVID-19; however, fetal outcomes are generally favorable. When unvaccinated, there was an increased risk of ICU admission for the mother.https://www.mdpi.com/2813-7914/1/4/43COVID-19pregnancyneonatesfetal deathpreterm birth |
| spellingShingle | Donna Mendez Krishna Paul Jerome L. Yaklic Dietrich Jehle Impacts of COVID-19 on Pregnancy Outcomes: A Retrospective Study Emergency Care and Medicine COVID-19 pregnancy neonates fetal death preterm birth |
| title | Impacts of COVID-19 on Pregnancy Outcomes: A Retrospective Study |
| title_full | Impacts of COVID-19 on Pregnancy Outcomes: A Retrospective Study |
| title_fullStr | Impacts of COVID-19 on Pregnancy Outcomes: A Retrospective Study |
| title_full_unstemmed | Impacts of COVID-19 on Pregnancy Outcomes: A Retrospective Study |
| title_short | Impacts of COVID-19 on Pregnancy Outcomes: A Retrospective Study |
| title_sort | impacts of covid 19 on pregnancy outcomes a retrospective study |
| topic | COVID-19 pregnancy neonates fetal death preterm birth |
| url | https://www.mdpi.com/2813-7914/1/4/43 |
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