Different n-6/n-3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic rats
Postprandial metabolism plays major roles in many pathological conditions. The n-6/n-3 polyunsaturated fatty acid (PUFA) ratio is closely related to various physiological disorders. This study aimed to investigate the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metab...
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Tsinghua University Press
2023-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022002609 |
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| author | Ligang Yang Chao Yang Zhixiu Song Min Wan Hui Xia Xian Yang Dengfeng Xu Da Pan Hechun Liu Shaokang Wang Guiju Sun |
| author_facet | Ligang Yang Chao Yang Zhixiu Song Min Wan Hui Xia Xian Yang Dengfeng Xu Da Pan Hechun Liu Shaokang Wang Guiju Sun |
| author_sort | Ligang Yang |
| collection | DOAJ |
| description | Postprandial metabolism plays major roles in many pathological conditions. The n-6/n-3 polyunsaturated fatty acid (PUFA) ratio is closely related to various physiological disorders. This study aimed to investigate the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control (NC) and hypertriglyceridemia (HTG) rats. The postprandial response of triglyceride (TG) in HTG groups was higher than that in NC groups after different n-6/n-3 PUFA ratio meals. The HTG groups showed higher postprandial total cholesterol (TC) responses than NC groups after 1:1 and 20:1 ratio meals. The 5:1 n-6/n-3 PUFA ratio elicited lower postprandial responses of tumor necrosis factor α (TNF-α) than 1:1 and 10:1 ratios in HTG groups. The postprandial malondialdehyde (MDA) response was lower after a 5:1 n-6/n-3 PUFA ratio meal than 1:1 and 20:1 ratio meals in HTG groups. The 1:1 ratio resulted in a lower postprandial reactive oxygen species (ROS) level than 5:1 and 10:1 n-6/n-3 PUFA ratios in NC groups. The results showed that a low n-6/n-3 PUFA ratio improved postprandial dysmetabolism induced by a high fat meal in NC and HTG rats. A high n-6/n-3 PUFA ratio increased the difference in postprandial metabolism between NC and HTG rats. |
| format | Article |
| id | doaj-art-b8ff8d029e8b46c2ba6c2ac7f8768027 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-b8ff8d029e8b46c2ba6c2ac7f87680272025-02-03T04:05:21ZengTsinghua University PressFood Science and Human Wellness2213-45302023-07-0112411571166Different n-6/n-3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic ratsLigang Yang0Chao Yang1Zhixiu Song2Min Wan3Hui Xia4Xian Yang5Dengfeng Xu6Da Pan7Hechun Liu8Shaokang Wang9Guiju Sun10Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, ChinaSecond Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; Corresponding author at: School of Public Health, Southeast University, Nanjing 210009, China.Postprandial metabolism plays major roles in many pathological conditions. The n-6/n-3 polyunsaturated fatty acid (PUFA) ratio is closely related to various physiological disorders. This study aimed to investigate the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control (NC) and hypertriglyceridemia (HTG) rats. The postprandial response of triglyceride (TG) in HTG groups was higher than that in NC groups after different n-6/n-3 PUFA ratio meals. The HTG groups showed higher postprandial total cholesterol (TC) responses than NC groups after 1:1 and 20:1 ratio meals. The 5:1 n-6/n-3 PUFA ratio elicited lower postprandial responses of tumor necrosis factor α (TNF-α) than 1:1 and 10:1 ratios in HTG groups. The postprandial malondialdehyde (MDA) response was lower after a 5:1 n-6/n-3 PUFA ratio meal than 1:1 and 20:1 ratio meals in HTG groups. The 1:1 ratio resulted in a lower postprandial reactive oxygen species (ROS) level than 5:1 and 10:1 n-6/n-3 PUFA ratios in NC groups. The results showed that a low n-6/n-3 PUFA ratio improved postprandial dysmetabolism induced by a high fat meal in NC and HTG rats. A high n-6/n-3 PUFA ratio increased the difference in postprandial metabolism between NC and HTG rats.http://www.sciencedirect.com/science/article/pii/S2213453022002609Polyunsaturated fatty acidn-6 Fatty acidsn-3 Fatty acids;Postprandial metabolismHypertriglyceridemia |
| spellingShingle | Ligang Yang Chao Yang Zhixiu Song Min Wan Hui Xia Xian Yang Dengfeng Xu Da Pan Hechun Liu Shaokang Wang Guiju Sun Different n-6/n-3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic rats Food Science and Human Wellness Polyunsaturated fatty acid n-6 Fatty acids n-3 Fatty acids; Postprandial metabolism Hypertriglyceridemia |
| title | Different n-6/n-3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic rats |
| title_full | Different n-6/n-3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic rats |
| title_fullStr | Different n-6/n-3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic rats |
| title_full_unstemmed | Different n-6/n-3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic rats |
| title_short | Different n-6/n-3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic rats |
| title_sort | different n 6 n 3 polyunsaturated fatty acid ratios affect postprandial metabolism in normal and hypertriglyceridemic rats |
| topic | Polyunsaturated fatty acid n-6 Fatty acids n-3 Fatty acids; Postprandial metabolism Hypertriglyceridemia |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022002609 |
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