Evaluation of Antitumer activity of Ammi Majus seeds extract on Some cancer cell line
Cancer is one of the major health problems in the world and is one of the important causes of an increase in deaths among children and adults , Today many of the treatment methods are used to treat cancer. Unfortunately, in most cases very poor response is often associated with undesirable side eff...
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College of science, university of Diyala
2025-01-01
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| Series: | Academic Science Journal |
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| Online Access: | https://acadscij.uodiyala.edu.iq/index.php/Home/article/view/279 |
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| author | Shahd Amer Ismael Izdehar Mohammed Jasim Saba Adnan Abbas |
| author_facet | Shahd Amer Ismael Izdehar Mohammed Jasim Saba Adnan Abbas |
| author_sort | Shahd Amer Ismael |
| collection | DOAJ |
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Cancer is one of the major health problems in the world and is one of the important causes of an increase in deaths among children and adults , Today many of the treatment methods are used to treat cancer. Unfortunately, in most cases very poor response is often associated with undesirable side effects has been made researchers to achieve more effective drugs with fewer side effects. The current study aimed to detect the effect of Ammi majus seeds extracts ( aqueous and ethanolic extracts) in treating somecancerous lines (HepG2 and Hela ) human cancer cell lines.The current study was perfomedin Iraqi Center for Cancer and Medical Genetics Research (ICCMGR) in Baghdad from December to March (2023). The cancer cell lines were treated with different concentrations (6.25 ,12.5 ,25, 50, 100,200 )of the Ammi majus seeds extracts (aqueous and ethanolic extracts).The results showed the effect of both seeds extracts (aqueous and alcoholic) on the growth of Helacell lines increased with increasing the concentration and give highest inhibition rate( 3.93 ± 72.69 % and 3.93± 91.87 ) in respectively ,at a concentration ( 200 µg/ml,)Wheareas the highest inhibition rate for the seedsextracts (aqueous and alcoholic) on the growth of HepG2 was ( 3.18 ± 68.86 % and 1.36± 79.31 %) in respectively, at a concentration ( 200µg/ml ), The current study concluded that the aqueous and alcoholic extracts of the Ammimajus seeds plant has an effect in the process of inhibiting cancer cell lines.making this plant a promising candidate for cancer treatment.
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| format | Article |
| id | doaj-art-b8f6ab11699a442e9af3098dd8b62b6f |
| institution | Kabale University |
| issn | 2958-4612 2959-5568 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | College of science, university of Diyala |
| record_format | Article |
| series | Academic Science Journal |
| spelling | doaj-art-b8f6ab11699a442e9af3098dd8b62b6f2025-02-04T04:26:33ZengCollege of science, university of DiyalaAcademic Science Journal2958-46122959-55682025-01-013110.24237/ASJ.03.01.836CEvaluation of Antitumer activity of Ammi Majus seeds extract on Some cancer cell lineShahd Amer Ismael0 Izdehar Mohammed Jasim1Saba Adnan Abbas2التربيهDepartment of Biology, College of Science, University of Diyala ,IraqDepartment of Biology, College of Science, University of Diyala ,Iraq Cancer is one of the major health problems in the world and is one of the important causes of an increase in deaths among children and adults , Today many of the treatment methods are used to treat cancer. Unfortunately, in most cases very poor response is often associated with undesirable side effects has been made researchers to achieve more effective drugs with fewer side effects. The current study aimed to detect the effect of Ammi majus seeds extracts ( aqueous and ethanolic extracts) in treating somecancerous lines (HepG2 and Hela ) human cancer cell lines.The current study was perfomedin Iraqi Center for Cancer and Medical Genetics Research (ICCMGR) in Baghdad from December to March (2023). The cancer cell lines were treated with different concentrations (6.25 ,12.5 ,25, 50, 100,200 )of the Ammi majus seeds extracts (aqueous and ethanolic extracts).The results showed the effect of both seeds extracts (aqueous and alcoholic) on the growth of Helacell lines increased with increasing the concentration and give highest inhibition rate( 3.93 ± 72.69 % and 3.93± 91.87 ) in respectively ,at a concentration ( 200 µg/ml,)Wheareas the highest inhibition rate for the seedsextracts (aqueous and alcoholic) on the growth of HepG2 was ( 3.18 ± 68.86 % and 1.36± 79.31 %) in respectively, at a concentration ( 200µg/ml ), The current study concluded that the aqueous and alcoholic extracts of the Ammimajus seeds plant has an effect in the process of inhibiting cancer cell lines.making this plant a promising candidate for cancer treatment. https://acadscij.uodiyala.edu.iq/index.php/Home/article/view/279Hela cancer cell line ;HepG2 cancer cell line , Ammi majus seeds extract |
| spellingShingle | Shahd Amer Ismael Izdehar Mohammed Jasim Saba Adnan Abbas Evaluation of Antitumer activity of Ammi Majus seeds extract on Some cancer cell line Academic Science Journal Hela cancer cell line ;HepG2 cancer cell line , Ammi majus seeds extract |
| title | Evaluation of Antitumer activity of Ammi Majus seeds extract on Some cancer cell line |
| title_full | Evaluation of Antitumer activity of Ammi Majus seeds extract on Some cancer cell line |
| title_fullStr | Evaluation of Antitumer activity of Ammi Majus seeds extract on Some cancer cell line |
| title_full_unstemmed | Evaluation of Antitumer activity of Ammi Majus seeds extract on Some cancer cell line |
| title_short | Evaluation of Antitumer activity of Ammi Majus seeds extract on Some cancer cell line |
| title_sort | evaluation of antitumer activity of ammi majus seeds extract on some cancer cell line |
| topic | Hela cancer cell line ;HepG2 cancer cell line , Ammi majus seeds extract |
| url | https://acadscij.uodiyala.edu.iq/index.php/Home/article/view/279 |
| work_keys_str_mv | AT shahdamerismael evaluationofantitumeractivityofammimajusseedsextractonsomecancercellline AT izdeharmohammedjasim evaluationofantitumeractivityofammimajusseedsextractonsomecancercellline AT sabaadnanabbas evaluationofantitumeractivityofammimajusseedsextractonsomecancercellline |