Long-term outcomes of gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty
Purpose This study aimed to examine the effects of gonadotropin-releasing hormone agonist (GnRHa) treatment on final height outcomes in girls with idiopathic central precocious puberty (CPP) from the start of treatment to their postmenarche visit. Methods We conducted a retrospective analysis of 200...
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Korean Society of Pediatric Endocrinology
2025-02-01
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| Series: | Annals of Pediatric Endocrinology & Metabolism |
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| Online Access: | http://e-apem.org/upload/pdf/apem-2448038-019.pdf |
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| author | Jung Hwangbo Eungu Kang Hyo-Kyoung Nam Young-Jun Rhie Kee-Hyoung Lee |
| author_facet | Jung Hwangbo Eungu Kang Hyo-Kyoung Nam Young-Jun Rhie Kee-Hyoung Lee |
| author_sort | Jung Hwangbo |
| collection | DOAJ |
| description | Purpose This study aimed to examine the effects of gonadotropin-releasing hormone agonist (GnRHa) treatment on final height outcomes in girls with idiopathic central precocious puberty (CPP) from the start of treatment to their postmenarche visit. Methods We conducted a retrospective analysis of 200 girls with idiopathic CPP who received GnRHa therapy, focusing on auxological and clinical outcomes at treatment initiation, treatment completion, and the last, postmenarche visit. Results The mean chronological age (CA) at GnRHa treatment initiation was 8.24±0.73 years. The mean duration of GnRHa treatment was 3.12±0.81 years. The average age at menarche was 12.73±0.56 years, occurring a mean of 17.15±5.52 months after completing GnRHa therapy. The predicted adult height (PAH) standard deviation score (SDS) after menarche (0.48±0.99) was significantly greater than before treatment (-1.33±1.46) (P<0.001). Factors including greater bone age advancement (P<0.001), lower height SDS for CA at treatment initiation (P<0.001), and higher midparental height SDS (P=0.001) were positively associated with an increase in PAH SDS at the last visit. However, near-final height and the increase in PAH SDS at the last visit were not significantly different between patients who received early treatment (<8 years) and those who received later treatment (8–9 years). Conclusions GnRHa treatment improved the final height outcomes in all girls with CPP, including those treated between 8 and 9 years of age. |
| format | Article |
| id | doaj-art-b8f37f35a5e7439a814bccbbee0dccf0 |
| institution | OA Journals |
| issn | 2287-1012 2287-1292 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Korean Society of Pediatric Endocrinology |
| record_format | Article |
| series | Annals of Pediatric Endocrinology & Metabolism |
| spelling | doaj-art-b8f37f35a5e7439a814bccbbee0dccf02025-08-20T02:19:19ZengKorean Society of Pediatric EndocrinologyAnnals of Pediatric Endocrinology & Metabolism2287-10122287-12922025-02-01301313710.6065/apem.2448038.0191080Long-term outcomes of gonadotropin-releasing hormone agonist treatment in girls with central precocious pubertyJung Hwangbo0Eungu Kang1Hyo-Kyoung Nam2Young-Jun RhieKee-Hyoung Lee3 Department of Pediatrics, Korea University College of Medicine, Seoul, Korea Department of Pediatrics, Korea University College of Medicine, Seoul, Korea Department of Pediatrics, Korea University College of Medicine, Seoul, Korea Department of Pediatrics, Korea University College of Medicine, Seoul, KoreaPurpose This study aimed to examine the effects of gonadotropin-releasing hormone agonist (GnRHa) treatment on final height outcomes in girls with idiopathic central precocious puberty (CPP) from the start of treatment to their postmenarche visit. Methods We conducted a retrospective analysis of 200 girls with idiopathic CPP who received GnRHa therapy, focusing on auxological and clinical outcomes at treatment initiation, treatment completion, and the last, postmenarche visit. Results The mean chronological age (CA) at GnRHa treatment initiation was 8.24±0.73 years. The mean duration of GnRHa treatment was 3.12±0.81 years. The average age at menarche was 12.73±0.56 years, occurring a mean of 17.15±5.52 months after completing GnRHa therapy. The predicted adult height (PAH) standard deviation score (SDS) after menarche (0.48±0.99) was significantly greater than before treatment (-1.33±1.46) (P<0.001). Factors including greater bone age advancement (P<0.001), lower height SDS for CA at treatment initiation (P<0.001), and higher midparental height SDS (P=0.001) were positively associated with an increase in PAH SDS at the last visit. However, near-final height and the increase in PAH SDS at the last visit were not significantly different between patients who received early treatment (<8 years) and those who received later treatment (8–9 years). Conclusions GnRHa treatment improved the final height outcomes in all girls with CPP, including those treated between 8 and 9 years of age.http://e-apem.org/upload/pdf/apem-2448038-019.pdfcentral precocious pubertygonadotropin-releasing hormone agonistpredicted adult heighttreatment outcomemenarche |
| spellingShingle | Jung Hwangbo Eungu Kang Hyo-Kyoung Nam Young-Jun Rhie Kee-Hyoung Lee Long-term outcomes of gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty Annals of Pediatric Endocrinology & Metabolism central precocious puberty gonadotropin-releasing hormone agonist predicted adult height treatment outcome menarche |
| title | Long-term outcomes of gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty |
| title_full | Long-term outcomes of gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty |
| title_fullStr | Long-term outcomes of gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty |
| title_full_unstemmed | Long-term outcomes of gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty |
| title_short | Long-term outcomes of gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty |
| title_sort | long term outcomes of gonadotropin releasing hormone agonist treatment in girls with central precocious puberty |
| topic | central precocious puberty gonadotropin-releasing hormone agonist predicted adult height treatment outcome menarche |
| url | http://e-apem.org/upload/pdf/apem-2448038-019.pdf |
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