CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers
The dysregulation of PD-1 ligands (PD-L1 and PD-L2) and CTLA-4 ligands (CD80 and CD86) represents a tumor strategy to escape the immune surveillance. Here, the expression of PD-L1, PD-L2, CD80, and CD86 was evaluated at the mRNA level in 94 patients affected by papillary thyroid carcinoma (PTC) and...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/1742951 |
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| author | Chiara Tuccilli Enke Baldini Salvatore Sorrenti Antonio Catania Alessandro Antonelli Poupak Fallahi Francesco Tartaglia Susi Barollo Caterina Mian Andrea Palmieri Giovanni Carbotta Stefano Arcieri Daniele Pironi Massimo Vergine Massimo Monti Salvatore Ulisse |
| author_facet | Chiara Tuccilli Enke Baldini Salvatore Sorrenti Antonio Catania Alessandro Antonelli Poupak Fallahi Francesco Tartaglia Susi Barollo Caterina Mian Andrea Palmieri Giovanni Carbotta Stefano Arcieri Daniele Pironi Massimo Vergine Massimo Monti Salvatore Ulisse |
| author_sort | Chiara Tuccilli |
| collection | DOAJ |
| description | The dysregulation of PD-1 ligands (PD-L1 and PD-L2) and CTLA-4 ligands (CD80 and CD86) represents a tumor strategy to escape the immune surveillance. Here, the expression of PD-L1, PD-L2, CD80, and CD86 was evaluated at the mRNA level in 94 patients affected by papillary thyroid carcinoma (PTC) and 11 patients affected by anaplastic thyroid carcinoma (ATC). Variations in the mRNAs in PTC patients were then correlated with clinicopathological features. The expression of all genes was deregulated in PTC and ATC tissues compared to normal tissues. In particular, the downregulation of CD80 was observed above all in ATC. In addition, the increased expression of CD80 associated with longer disease-free survival in PTC. Higher expression of PD-L1 associated with the classical histological variant and with the presence of BRAFV600E mutation in PTC. The increased PD-L2 expression correlated with BRAFV600E mutation and lymph node metastasis, while its lower expression correlated with the follicular PTC variant. The latter was also associated with the CD80 downregulation, which was also related to the absence of lymph node metastasis. In conclusion, we documented the overall dysregulation of PD-1 and CTLA-4 ligands in PTC and ATC tissues and a possible prognostic value for CD80 gene expression in PTC. |
| format | Article |
| id | doaj-art-b8efa05d62704217b8d394778dd79795 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-b8efa05d62704217b8d394778dd797952025-02-03T07:24:58ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/17429511742951CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid CancersChiara Tuccilli0Enke Baldini1Salvatore Sorrenti2Antonio Catania3Alessandro Antonelli4Poupak Fallahi5Francesco Tartaglia6Susi Barollo7Caterina Mian8Andrea Palmieri9Giovanni Carbotta10Stefano Arcieri11Daniele Pironi12Massimo Vergine13Massimo Monti14Salvatore Ulisse15Department of Surgical Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Medicine, University of Padua, Padua, ItalyDepartment of Medicine, University of Padua, Padua, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, Rome, ItalyThe dysregulation of PD-1 ligands (PD-L1 and PD-L2) and CTLA-4 ligands (CD80 and CD86) represents a tumor strategy to escape the immune surveillance. Here, the expression of PD-L1, PD-L2, CD80, and CD86 was evaluated at the mRNA level in 94 patients affected by papillary thyroid carcinoma (PTC) and 11 patients affected by anaplastic thyroid carcinoma (ATC). Variations in the mRNAs in PTC patients were then correlated with clinicopathological features. The expression of all genes was deregulated in PTC and ATC tissues compared to normal tissues. In particular, the downregulation of CD80 was observed above all in ATC. In addition, the increased expression of CD80 associated with longer disease-free survival in PTC. Higher expression of PD-L1 associated with the classical histological variant and with the presence of BRAFV600E mutation in PTC. The increased PD-L2 expression correlated with BRAFV600E mutation and lymph node metastasis, while its lower expression correlated with the follicular PTC variant. The latter was also associated with the CD80 downregulation, which was also related to the absence of lymph node metastasis. In conclusion, we documented the overall dysregulation of PD-1 and CTLA-4 ligands in PTC and ATC tissues and a possible prognostic value for CD80 gene expression in PTC.http://dx.doi.org/10.1155/2018/1742951 |
| spellingShingle | Chiara Tuccilli Enke Baldini Salvatore Sorrenti Antonio Catania Alessandro Antonelli Poupak Fallahi Francesco Tartaglia Susi Barollo Caterina Mian Andrea Palmieri Giovanni Carbotta Stefano Arcieri Daniele Pironi Massimo Vergine Massimo Monti Salvatore Ulisse CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers International Journal of Endocrinology |
| title | CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers |
| title_full | CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers |
| title_fullStr | CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers |
| title_full_unstemmed | CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers |
| title_short | CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers |
| title_sort | ctla 4 and pd 1 ligand gene expression in epithelial thyroid cancers |
| url | http://dx.doi.org/10.1155/2018/1742951 |
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