Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases
Retinal degenerative diseases are major causes of vision loss and blindness worldwide and are characterized by chronic and progressive neuronal loss. One common feature of retinal degenerative diseases and brain neurodegenerative diseases is chronic neuroinflammation. There is growing evidence that...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/673090 |
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| _version_ | 1832545808116875264 |
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| author | Maria H. Madeira Raquel Boia Paulo F. Santos António F. Ambrósio Ana R. Santiago |
| author_facet | Maria H. Madeira Raquel Boia Paulo F. Santos António F. Ambrósio Ana R. Santiago |
| author_sort | Maria H. Madeira |
| collection | DOAJ |
| description | Retinal degenerative diseases are major causes of vision loss and blindness worldwide and are characterized by chronic and progressive neuronal loss. One common feature of retinal degenerative diseases and brain neurodegenerative diseases is chronic neuroinflammation. There is growing evidence that retinal microglia, as in the brain, become activated in the course of retinal degenerative diseases, having a pivotal role in the initiation and propagation of the neurodegenerative process. A better understanding of the events elicited and mediated by retinal microglia will contribute to the clarification of disease etiology and might open new avenues for potential therapeutic interventions. This review aims at giving an overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy. |
| format | Article |
| id | doaj-art-b8eb38d4c7624f4e99052b72c6dd6915 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b8eb38d4c7624f4e99052b72c6dd69152025-02-03T07:24:39ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/673090673090Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative DiseasesMaria H. Madeira0Raquel Boia1Paulo F. Santos2António F. Ambrósio3Ana R. Santiago4Centre of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3004-548 Coimbra, PortugalCentre of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3004-548 Coimbra, PortugalCentre of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3004-548 Coimbra, PortugalCentre of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3004-548 Coimbra, PortugalCentre of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3004-548 Coimbra, PortugalRetinal degenerative diseases are major causes of vision loss and blindness worldwide and are characterized by chronic and progressive neuronal loss. One common feature of retinal degenerative diseases and brain neurodegenerative diseases is chronic neuroinflammation. There is growing evidence that retinal microglia, as in the brain, become activated in the course of retinal degenerative diseases, having a pivotal role in the initiation and propagation of the neurodegenerative process. A better understanding of the events elicited and mediated by retinal microglia will contribute to the clarification of disease etiology and might open new avenues for potential therapeutic interventions. This review aims at giving an overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy.http://dx.doi.org/10.1155/2015/673090 |
| spellingShingle | Maria H. Madeira Raquel Boia Paulo F. Santos António F. Ambrósio Ana R. Santiago Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases Mediators of Inflammation |
| title | Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases |
| title_full | Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases |
| title_fullStr | Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases |
| title_full_unstemmed | Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases |
| title_short | Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases |
| title_sort | contribution of microglia mediated neuroinflammation to retinal degenerative diseases |
| url | http://dx.doi.org/10.1155/2015/673090 |
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