G-CSF-Associated Bone Marrow Necrosis in AML after Induction Chemotherapy
Bone marrow necrosis (BMN) is defined as necrosis of the myeloid tissues and stroma without involvement of the cortical bone. We report a case of 66-year-old male with AML-M4 (FAB classification) who was given induction chemotherapy with cytarabine and daunorubicin. Filgrastim at 480 micrograms was...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/314278 |
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| _version_ | 1832550027040391168 |
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| author | Ikenna Osuorji Lyle Goldman |
| author_facet | Ikenna Osuorji Lyle Goldman |
| author_sort | Ikenna Osuorji |
| collection | DOAJ |
| description | Bone marrow necrosis (BMN) is defined as necrosis of the myeloid tissues and stroma without involvement of the cortical bone. We report a case of 66-year-old male with AML-M4 (FAB classification) who was given induction chemotherapy with cytarabine and daunorubicin. Filgrastim at 480 micrograms was administered on days 15–19 to shorten the duration of neutropenia. Consequently patient developed severe pelvic bone pain, leukoerythroblastosis, and severe leukocytosis. Repeat bone marrow aspiration and biopsy on day 21 confirmed bone marrow necrosis. These manifestations responded quickly to discontinuation of filgrastim. Subsequently, he recovered full myelopoiesis. We suggest that there may be more cases of BMN associated with G-CSF that are undiagnosed. |
| format | Article |
| id | doaj-art-b8db24968c23404dbade0439b8aed20f |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-b8db24968c23404dbade0439b8aed20f2025-02-03T06:07:55ZengWileyCase Reports in Hematology2090-65602090-65792012-01-01201210.1155/2012/314278314278G-CSF-Associated Bone Marrow Necrosis in AML after Induction ChemotherapyIkenna Osuorji0Lyle Goldman1Department of Hematology and Oncology, Providence Cancer Institute, 22301 Foster Winter Drive, Southfield, MI 48075, USADepartment of Hematology and Oncology, Providence Cancer Institute, 22301 Foster Winter Drive, Southfield, MI 48075, USABone marrow necrosis (BMN) is defined as necrosis of the myeloid tissues and stroma without involvement of the cortical bone. We report a case of 66-year-old male with AML-M4 (FAB classification) who was given induction chemotherapy with cytarabine and daunorubicin. Filgrastim at 480 micrograms was administered on days 15–19 to shorten the duration of neutropenia. Consequently patient developed severe pelvic bone pain, leukoerythroblastosis, and severe leukocytosis. Repeat bone marrow aspiration and biopsy on day 21 confirmed bone marrow necrosis. These manifestations responded quickly to discontinuation of filgrastim. Subsequently, he recovered full myelopoiesis. We suggest that there may be more cases of BMN associated with G-CSF that are undiagnosed.http://dx.doi.org/10.1155/2012/314278 |
| spellingShingle | Ikenna Osuorji Lyle Goldman G-CSF-Associated Bone Marrow Necrosis in AML after Induction Chemotherapy Case Reports in Hematology |
| title | G-CSF-Associated Bone Marrow Necrosis in AML after Induction Chemotherapy |
| title_full | G-CSF-Associated Bone Marrow Necrosis in AML after Induction Chemotherapy |
| title_fullStr | G-CSF-Associated Bone Marrow Necrosis in AML after Induction Chemotherapy |
| title_full_unstemmed | G-CSF-Associated Bone Marrow Necrosis in AML after Induction Chemotherapy |
| title_short | G-CSF-Associated Bone Marrow Necrosis in AML after Induction Chemotherapy |
| title_sort | g csf associated bone marrow necrosis in aml after induction chemotherapy |
| url | http://dx.doi.org/10.1155/2012/314278 |
| work_keys_str_mv | AT ikennaosuorji gcsfassociatedbonemarrownecrosisinamlafterinductionchemotherapy AT lylegoldman gcsfassociatedbonemarrownecrosisinamlafterinductionchemotherapy |